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Social and Behavioral Sciences Commons™
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- Faculty of Health and Behavioural Sciences - Papers (Archive) (3)
- Psychology Faculty Publications (2)
- Sanders-Brown Center on Aging Faculty Publications (2)
- Sentience Collection (2)
- Sturm College of Law: Faculty Scholarship (2)
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- Assessment of Animal Welfare Collection (1)
- Dartmouth Scholarship (1)
- Experimentation Collection (1)
- Faculty of Science - Papers (Archive) (1)
- Honors Scholar Theses (1)
- Journal Articles (1)
- Natural Science Student Work (1)
- Publications and Research (1)
- Select or Award-Winning Individual Scholarship (1)
- Senior Honors Projects (1)
Articles 1 - 21 of 21
Full-Text Articles in Social and Behavioral Sciences
Buprenorphine Effects On Anxiety-Like Behavior In B6 Mice, Megan K. Thibert
Buprenorphine Effects On Anxiety-Like Behavior In B6 Mice, Megan K. Thibert
Select or Award-Winning Individual Scholarship
Buprenorphine, a semi-synthetic opioid prescribed for the treatment of opioid use disorder (OUD), has been suggested as a potential pharmacological treatment for anxiety. Some preclinical and clinical studies provide support for the anxiolytic effects of buprenorphine, but research in this area is scarce, and findings to date have been mixed. The present study was designed to test the hypothesis that buprenorphine alters anxiety-like behavior in C57BL/IJ (B6) mice measured using the elevated zero maze (EZM). Adult, male mice (n=10) were given subcutaneous injections of saline (control) and three doses of buprenorphine (0.3, 1, and 10 mg/kg). One hour following injection, …
The Disproportionate Impact Of Covid-19 On Women, Ava Stallone
The Disproportionate Impact Of Covid-19 On Women, Ava Stallone
Honors Scholar Theses
The impact of COVID-19 is placing a large strain on women. This can be seen through reports of mental health and financial concerns. Women are more vulnerable to COVID-19 related economic effects due to existing gender inequalities, which in turn may also have a negative effect on mental health. Through this study gender disproportion is looked at between mental health and COVID-19 financial concerns among women and men. The aim is to asses how COVID-19 financial concerns may be contributing to stress, anxiety, and depression. It is hypothesized that; women will report worse mental health and greater economic concerns than …
Maternal Cannabis Use Is Associated With Suppression Of Immune Gene Networks In Placenta And Increased Anxiety Phenotypes In Offspring, Gregory Rompala, Yoko Nomura, Yasmin L. Hurd
Maternal Cannabis Use Is Associated With Suppression Of Immune Gene Networks In Placenta And Increased Anxiety Phenotypes In Offspring, Gregory Rompala, Yoko Nomura, Yasmin L. Hurd
Publications and Research
While cannabis is among the most used recreational drugs during pregnancy, the impact of maternal cannabis use (mCB) on fetal and child development remains unclear. Here, we assessed the effects of mCB on psychosocial and physiological measures in young children along with the potential relevance of the in-utero environment reflected in the placental transcriptome. Children (~3-6 years) were assessed for hair hormone levels, neurobehavioral traits on the behavioral assessment system for children (BASC-2) survey, and heart rate variability (HRV) at rest and during auditory startle. For a subset of children with behavioral assessments, placental specimens collected at birth were processed …
Evaluating Implicit Self-Compassion In College Students, Emily Kutok
Evaluating Implicit Self-Compassion In College Students, Emily Kutok
Senior Honors Projects
Typically, research on self-compassion and mental health has used the measurement tool of self-report (explicit) surveys to examine self-compassion. Implicit Association Tests (IAT) can be applied to a number of di erent constructs, some of which include racial biases, gender stereotypes, and suicidal ideation. ey are used to measure the strength of a person’s automatic association between two concepts (in this case, between self and compassion). By measuring implicit self-compassion, a researcher can expect less self-report bias related to self- presentational concerns and the limits of introspection, and they can capture psychological processes that occur without full conscious awareness but …
Age Drives Distortion Of Brain Metabolic, Vascular And Cognitive Functions, And The Gut Microbiome, Jared D. Hoffman, Ishita Parikh, Stefan J. Green, George Chlipala, Robert P. Mohney, Mignon Keaton, Bjoern Bauer, Anika M. S. Hartz, Ai-Ling Lin
Age Drives Distortion Of Brain Metabolic, Vascular And Cognitive Functions, And The Gut Microbiome, Jared D. Hoffman, Ishita Parikh, Stefan J. Green, George Chlipala, Robert P. Mohney, Mignon Keaton, Bjoern Bauer, Anika M. S. Hartz, Ai-Ling Lin
Sanders-Brown Center on Aging Faculty Publications
Advancing age is the top risk factor for the development of neurodegenerative disorders, including Alzheimer’s disease (AD). However, the contribution of aging processes to AD etiology remains unclear. Emerging evidence shows that reduced brain metabolic and vascular functions occur decades before the onset of cognitive impairments, and these reductions are highly associated with low-grade, chronic inflammation developed in the brain over time. Interestingly, recent findings suggest that the gut microbiota may also play a critical role in modulating immune responses in the brain via the brain-gut axis. In this study, our goal was to identify associations between deleterious changes in …
Impact Of Stress, Fear And Anxiety On The Nociceptive Responses Of Larval Zebrafish, Javier Lopez-Luna, Qussay Al-Jubouri, Lynne U. Sneddon
Impact Of Stress, Fear And Anxiety On The Nociceptive Responses Of Larval Zebrafish, Javier Lopez-Luna, Qussay Al-Jubouri, Lynne U. Sneddon
Sentience Collection
Both adult and larval zebrafish have been demonstrated to show behavioural responses to noxious stimulation but also to potentially stress- and fear or anxiety- eliciting situations. The pain or nociceptive response can be altered and modulated by these situations in adult fish through a mechanism called stress-induced analgesia. However, this phenomenon has not been described in larval fish yet. Therefore, this study explores the behavioural changes in larval zebrafish after noxious stimulation and exposure to challenges that can trigger a stress, fear or anxiety reaction. Five-day post fertilization zebrafish were exposed to either a stressor (air emersion), a predatory fear …
Neurotensin Nts1 And Nts2 Receptor Agonists Produce Anxiolytic-Like Effects In The 22-Khz Ultrasonic Vocalization Model In Rats, Floyd F. Steele Iii, Shannon C. Whitehouse, Jacob S. Aday, Adam J. Prus
Neurotensin Nts1 And Nts2 Receptor Agonists Produce Anxiolytic-Like Effects In The 22-Khz Ultrasonic Vocalization Model In Rats, Floyd F. Steele Iii, Shannon C. Whitehouse, Jacob S. Aday, Adam J. Prus
Journal Articles
Neurotensin is a neuropeptide neurotransmitter that interacts with multiple neurotransmitter systems, including those regulating amygdalar function, via NTS1 and NTS2 receptors. Both receptors are expressed in the amygdala and agonists for NTS1 or NTS2 receptors have exhibited anxiolytic effects in animal models. Systemic adminstration of NTS1 receptor agonist PD149163 was recently shown to reduce footshock conditioned 22-kHz ultrasonic vocalizations in rats, suggesting that PD149163 produced an anxiolytic effect. The effects that neurotensin may have or a selective NTS2receptor agonist may have on 22-kHz vocalizations has yet to be examined. The current study evaluated …
Caloric Restriction Preserves Memory And Reduces Anxiety Of Aging Mice With Early Enhancement Of Neurovascular Functions, Ishita Parikh, Janet Guo, Kai-Hsiang Chuang, Yu Zhong, Ralf G. Rempe, Jared D. Hoffman, Rachel Armstrong, Björn Bauer, Anika M. S. Hartz, Ai-Ling Lin
Caloric Restriction Preserves Memory And Reduces Anxiety Of Aging Mice With Early Enhancement Of Neurovascular Functions, Ishita Parikh, Janet Guo, Kai-Hsiang Chuang, Yu Zhong, Ralf G. Rempe, Jared D. Hoffman, Rachel Armstrong, Björn Bauer, Anika M. S. Hartz, Ai-Ling Lin
Sanders-Brown Center on Aging Faculty Publications
Neurovascular integrity plays an important role in protecting cognitive and mental health in aging. Lifestyle interventions that sustain neurovascular integrity may thus be critical on preserving brain functions in aging and reducing the risk for age-related neurodegenerative disorders. Here we show that caloric restriction (CR) had an early effect on neurovascular enhancements, and played a critical role in preserving vascular, cognitive and mental health in aging. In particular, we found that CR significantly enhanced cerebral blood flow (CBF) and blood-brain barrier function in young mice at 5-6 months of age. The neurovascular enhancements were associated with reduced mammalian target of …
Drink Like A Lawyer: The Neuroscience Of Substance Use And Its Impact On Cognitive Wellness, Debra S. Austin
Drink Like A Lawyer: The Neuroscience Of Substance Use And Its Impact On Cognitive Wellness, Debra S. Austin
Sturm College of Law: Faculty Scholarship
Lawyers suffer from higher levels of anxiety and depression than the rest of the population, but most do not enter law school with these mental health issues. Disciplinary actions against attorneys involve substance abuse 50 to 75 percent of the time. However, neuroscience research has shown that both the brain and the genes enjoy the power of plasticity, which means that personal choices and environments shape the development of lawyers throughout their lives. Legal educators need a better understanding of what aspects or characteristics of legal education contribute to the decline in mental health of law students, lawyers, and judges, …
Combatting Dental Anxiety In Patients, Gretchen Osdoba
Combatting Dental Anxiety In Patients, Gretchen Osdoba
Natural Science Student Work
Dental Anxiety is a highly debilitating condition that can keep people away from the dentist and from receiving critical care. This can lead to serious medical conditions that could have easily been prevented through proper dental care. The purpose of this paper is to describe the nature of dental fear and the different treatment options available. I will focus on helpful traits of dentists and the use of psychological treatments, nitrous oxide, anti-anxiety medications, and general anesthesia to reduce this fear. I will also discuss a comparison of a psychological treatment and an anti-anxiety medication as short-term and long-term treatment …
Nutrition Status Of Primary Care Patients With Depression And Anxiety, Adrienne K. Forsyth, Peter G. Williams, Frank P. Deane
Nutrition Status Of Primary Care Patients With Depression And Anxiety, Adrienne K. Forsyth, Peter G. Williams, Frank P. Deane
Faculty of Health and Behavioural Sciences - Papers (Archive)
The objective of this study was to evaluate the nutrition status of people referred to a nutrition and physical activity program for the management of mental health in a general practice.
Behind The Mask: The Influence Of Mask-Type On Amygdala Response To Fearful Faces, M Justin Kim, Rebecca A. Loucks, Maital Neta, F. Caroline Davis, Jonathan A. Oler, Emily C. Mazzulla, Paul J. Whalen
Behind The Mask: The Influence Of Mask-Type On Amygdala Response To Fearful Faces, M Justin Kim, Rebecca A. Loucks, Maital Neta, F. Caroline Davis, Jonathan A. Oler, Emily C. Mazzulla, Paul J. Whalen
Dartmouth Scholarship
In this study, we compared the effects of using neutral face masks vs non-face pattern masks on amygdala activity to masked fearful faces. Twenty-seven subjects viewed 18 s blocks of either fearful or happy faces masked with either neutral faces or patterns, while their brain activity was measured using functional magnetic resonance imaging. Results replicated increased amygdala activation to face-masked fearful vs happy faces. In the pattern mask condition, the amygdala discriminated between masked fearful and happy faces, but this effect manifested as a decrease in activation to fearful faces compared to happy faces. This interactive effect between facial expression …
Effects Of Chlordiazepoxide On Predator Odor-Induced Reductions Of Playfulness In Juvenile Rats, Stephen M. Siviy, Courtney L. Steets, Lauren M. Debrouse
Effects Of Chlordiazepoxide On Predator Odor-Induced Reductions Of Playfulness In Juvenile Rats, Stephen M. Siviy, Courtney L. Steets, Lauren M. Debrouse
Psychology Faculty Publications
The extent to which a non-sedative dose of chlordiazepoxide (CDP) is able to modify the behavioral responses toward a predator odor was assessed in juvenile rats. Play behavior was suppressed and defensive behaviors were enhanced in the presence of a collar previously worn by a cat, when tested 24 hours later in the same context as that where the exposure occurred, and when tested in a context different than that in which the exposure occurred for up to 3 hours after exposure. CDP had no effect on the ability of cat odor to suppress play when rats were tested in …
Ecstasy (Mdma) And Its Relationship With Self Report Depression, Anxiety And Schizotypy, Lisa Woods, Emma Barkus
Ecstasy (Mdma) And Its Relationship With Self Report Depression, Anxiety And Schizotypy, Lisa Woods, Emma Barkus
Faculty of Health and Behavioural Sciences - Papers (Archive)
Abstract. Aims: The relationship between ecstasy and affective psychological symptoms are still subject to debate. We aimed to examine the relationship between Ecstasy use and self-report depression, anxiety and schizotypy. Design: Data were collected via structured remote self-report questionnaires. Participants: Participants were split into three groups: a control group with no ecstasy use, a light ecstasy user group (<50 >times), and a heavy ecstasy user group (>50 times). Measurements: Amount and patterns of ecstasy use were recorded, the Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) measured depression and anxiety respectively, and schizotypal traits were measured using the …
Library Anxiety Of Law Students: A Study Utilizing The Multidimensional Library Anxiety Scale, Stacey L. Bowers
Library Anxiety Of Law Students: A Study Utilizing The Multidimensional Library Anxiety Scale, Stacey L. Bowers
Sturm College of Law: Faculty Scholarship
The purpose of this study was to determine whether law students experienced library anxiety and, if so, which components contributed to that anxiety. The Multidimensional Library Anxiety Scale (mlas) developed by Dr. Doris Van Kampen was used to assess library anxiety levels of law students. The mlas is a 53 question Likert scale instrument that measures the construct of library anxiety. Participants in the study were law students enrolled in a private midwestern university during the 2009-2010 academic year who completed the survey instrument. Law students are a unique graduate school population who undergo an extremely rigorous and competitive course …
Play And Adversity: How The Playful Mammalian Brain Withstands Threats And Anxieties, Stephen M. Siviy
Play And Adversity: How The Playful Mammalian Brain Withstands Threats And Anxieties, Stephen M. Siviy
Psychology Faculty Publications
Most mammals play, but they do so in a dangerous world. The dynamic relationship between the stresses created by their world and the activity of play helps to explain the evolution of play in mammals, as the author demonstrates in evidence garnered from experiments that introduce elements of fear to rats at play. The author describes the resulting fearful behavior and quantifies the fluctuation in play that results, and then he investigates how these are modified by increased maternal care or the use of benzodiazepines. In conclusion, he discusses how such research can help shed light on the neurobiology underlying …
Addressing Distress And Pain In Animal Research: The Veterinary, Research, Societal, Regulatory And Ethical Contexts For Moving Forward, Kathleen Conlee, Martin Stephens, Andrew N. Rowan
Addressing Distress And Pain In Animal Research: The Veterinary, Research, Societal, Regulatory And Ethical Contexts For Moving Forward, Kathleen Conlee, Martin Stephens, Andrew N. Rowan
Experimentation Collection
While most people recognize that biomedical scientists are searching for knowledge that will improve the health of humans and animals, the image of someone deliberately causing harm to an animal in order to produce data that may lead to some future benefit has always prompted an uncomfortable reaction outside the laboratory. However, proponents of animal research have usually justified the practice by reference to greater benefits (new knowledge and medical treatments) over lesser costs (in animal suffering and death). Given that one of the costs of animal research is the suffering experienced by the animals, the goal of eliminating distress …
A Hypomorphic Vasopressin Allele Prevents Anxiety-Related Behavior, Mirjam Bunck, Ludwig Czibere, Charlotte Horvath, Cornelia Graf, Elisabeth T. Frank, Melanie S. Kebler, Chris Murgatroyd, Bertram Muller-Myhsok, Mariya Gonik, Peter Weber, Benno Putz, Patrik Muigg, Markus Panhuysen, Nicolas Singewald, Thomas Bettecken, Jan M. Deussing, Florian Holsboer, Dietmar Spengler, Rainer Landgraf
A Hypomorphic Vasopressin Allele Prevents Anxiety-Related Behavior, Mirjam Bunck, Ludwig Czibere, Charlotte Horvath, Cornelia Graf, Elisabeth T. Frank, Melanie S. Kebler, Chris Murgatroyd, Bertram Muller-Myhsok, Mariya Gonik, Peter Weber, Benno Putz, Patrik Muigg, Markus Panhuysen, Nicolas Singewald, Thomas Bettecken, Jan M. Deussing, Florian Holsboer, Dietmar Spengler, Rainer Landgraf
Faculty of Science - Papers (Archive)
In this study, microarray analysis, in situ hybridization, quantitative real-time PCR and immunohistochemistry revealed decreased expression of the vasopressin gene (Avp) in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei of adult LAB mice compared to HAB, NAB (normal anxiety-related behavior) and HABxLAB F1 intercross controls, without detecting differences in receptor expression or density. By sequencing the regions 2.5 kbp up- and downstream of the Avp gene locus, we could identify several polymorphic loci, differing between the HAB and LAB lines. In the gene promoter, a deletion of twelve bp Δ(−2180–2191) is particularly likely to contribute to the reduced Avp …
The Relationship Between Driving Anxiety And Driving Skill: A Review Of Human Factors And Anxiety-Performance Theories To Clarify Future Research Needs, Joanne Taylor, Frank P. Deane, John Podd
The Relationship Between Driving Anxiety And Driving Skill: A Review Of Human Factors And Anxiety-Performance Theories To Clarify Future Research Needs, Joanne Taylor, Frank P. Deane, John Podd
Faculty of Health and Behavioural Sciences - Papers (Archive)
This article examines theory and identifies gaps in research related to the role of driving skills in driving anxiety. Increasingly, investigators have examined the clinical features of driving anxiety and the more severe situation of driving fear and phobia, but the possible involvement of driving skills has been neglected. This is surprising given the potential implications for skills training and remediation in the assessment and treatment of some of those who experience driving anxiety, fear, and phobia. The largest body of relevant research comes from the driving and human factors literature on the relationship between anxiety and driving performance. The …
Evaluation Of Animal Welfare By The Self-Expression Of An Anxiety State, M. P. Carey, J. P. Fry
Evaluation Of Animal Welfare By The Self-Expression Of An Anxiety State, M. P. Carey, J. P. Fry
Assessment of Animal Welfare Collection
Although mental well-being has long been accepted as an important aspect of animal welfare, the subjective feelings of farm or laboratory animals are regarded as lying beyond the scope of scientific enquiry. We now report that pharmacological conditioning of pigs with a drug, pentylenetetrazole, known to induce anxiety in man, permits investigation of the presence or absence of this psychological state during exposure to a variety of environmental stimuli encountered during normal husbandry. Such pharmacological conditioning therefore provides a valuable means to assess and improve elements of animal welfare and should be applicable to other species that show operant behaviour.
The Problem Of Pain: What Do Animals Really Feel?, Dana H. Murphy
The Problem Of Pain: What Do Animals Really Feel?, Dana H. Murphy
Sentience Collection
Much of the contention and confusion that seem inevitably to arise whenever the subject of pain in animals comes up appear to stem principally from problems with the word "pain" itself. When used to describe responses in humans, "pain" can mean any subset of an incredibly broad spectrum of sensations and emotions, ranging from the instantaneous, galvanizing effect of a dentist drill hitting the nerve in a molar, to more airy notions such as the "pain" of rejection or "painfully" embarrassing situations. Humans even use concepts as abstruse as the German term, weltschmerz, or "world pain," which denotes a vaguely …