Social and Behavioral Sciences Commons^™

A Hypomorphic Vasopressin Allele Prevents Anxiety-Related Behavior, Mirjam Bunck, Ludwig Czibere, Charlotte Horvath, Cornelia Graf, Elisabeth T. Frank, Melanie S. Kebler, Chris Murgatroyd, Bertram Muller-Myhsok, Mariya Gonik, Peter Weber, Benno Putz, Patrik Muigg, Markus Panhuysen, Nicolas Singewald, Thomas Bettecken, Jan M. Deussing, Florian Holsboer, Dietmar Spengler, Rainer Landgraf

Faculty of Science - Papers (Archive)

In this study, microarray analysis, in situ hybridization, quantitative real-time PCR and immunohistochemistry revealed decreased expression of the vasopressin gene (Avp) in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei of adult LAB mice compared to HAB, NAB (normal anxiety-related behavior) and HABxLAB F1 intercross controls, without detecting differences in receptor expression or density. By sequencing the regions 2.5 kbp up- and downstream of the Avp gene locus, we could identify several polymorphic loci, differing between the HAB and LAB lines. In the gene promoter, a deletion of twelve bp Δ(−2180–2191) is particularly likely to contribute to the reduced Avp …