Social and Behavioral Sciences Commons^™

An Investigation Of Propranolol As An Agent For The Experimental Manipulation Of Interoception., Jane Evguenia Kouptsova

Electronic Thesis and Dissertation Repository

Interoception has recently come under research focus as a potential influence on emotional and epistemic feelings. However, existing means to manipulate it experimentally have conceptual or logistical drawbacks. We investigated whether 20 mg of propranolol is a viable agent for experimentally manipulating interoception. Thirteen participants completed a double-blind, placebo-controlled crossover study, performing two heartbeat perception tasks, control tasks and measures of anxiety and alertness. All measures were obtained at the beginning and end of both sessions. Propranolol significantly decreased heart rate and systolic blood pressure. Heartbeat detection performance numerically decreased under propranolol, although this effect failed to reach statistical significance. …