Social and Behavioral Sciences Commons^™

Modeling The Psychiatric Aspects Of Polycystic Ovary Syndrome And Induced Stress, Danielle Peecher

All Master's Theses

Polycystic ovary syndrome (PCOS) is an endocrine disorder in women that is characterized by excess testosterone and is associated with increased risk of infertility. Women with PCOS also show higher rates of depression and anxiety. Modeling PCOS in mice via administration of dihydrotestosterone (DHT) results in physiological alterations that are consistent with the physiological symptoms of PCOS in women. While some studies have investigated behavioral changes in PCOS mouse models, findings have varied. Thus, the current research examined whether a PCOS model with an additional stress factor resulted in behavioral changes. To create a stress condition, subjects were implanted with …