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Social and Behavioral Sciences Commons™
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Articles 1 - 6 of 6
Full-Text Articles in Social and Behavioral Sciences
Intracranial Injection Of Gammagard, A Human Ivig, Modulates The Inflammatory Response Of The Brain And Lowers AΒ In App/Ps1 Mice Along A Different Time Course Than Anti-AΒ Antibodies, Tiffany L. Sudduth, Abigail Greenstein, Donna M. Wilcock
Intracranial Injection Of Gammagard, A Human Ivig, Modulates The Inflammatory Response Of The Brain And Lowers AΒ In App/Ps1 Mice Along A Different Time Course Than Anti-AΒ Antibodies, Tiffany L. Sudduth, Abigail Greenstein, Donna M. Wilcock
Sanders-Brown Center on Aging Faculty Publications
Gammagard IVIg is a therapeutic approach to treat Alzheimer's disease currently in phase 3 clinical trials. Despite the reported efficacy of the approach the mechanism of action is poorly understood. We have previously shown that intracranial injection of anti-Aβ antibodies into the frontal cortex and hippocampus reveals important information regarding the time course of events once the agent is in the brain. In the current study we compared IVIg, mouse-pooled IgG, and the anti-Aβ antibody 6E10 injected intracranially into the frontal cortex and hippocampus of 7-month-old APP/PS1 mice. We established a time course of events ranging from 1 …
Comprehensive Behavioral Characterization Of An App/Ps-1 Double Knock-In Mouse Model Of Alzheimer's Disease, Scott J. Webster, Adam D. Bachstetter, Linda J. Van Eldik
Comprehensive Behavioral Characterization Of An App/Ps-1 Double Knock-In Mouse Model Of Alzheimer's Disease, Scott J. Webster, Adam D. Bachstetter, Linda J. Van Eldik
Sanders-Brown Center on Aging Faculty Publications
INTRODUCTION: Despite the extensive mechanistic and pathological characterization of the amyloid precursor protein (APP)/presenilin-1 (PS-1) knock-in mouse model of Alzheimer's disease (AD), very little is known about the AD-relevant behavioral deficits in this model. Characterization of the baseline behavioral performance in a variety of functional tasks and identification of the temporal onset of behavioral impairments are important to provide a foundation for future preclinical testing of AD therapeutics. Here we perform a comprehensive behavioral characterization of this model, discuss how the observed behavior correlates with the mechanistic and pathological observations of others, and compare this model with other commonly used …
Wisdom, Resilience And Successful Aging: Changing Public Discourses On Living With Dementia, Phyllis Braudy Harris, John Keady
Wisdom, Resilience And Successful Aging: Changing Public Discourses On Living With Dementia, Phyllis Braudy Harris, John Keady
Phyllis Braudy Harris
No abstract provided.
The Journal's 10 Year Anniversary - Looking Back And Moving Forward, Phyllis Braudy Harris, John Keady
The Journal's 10 Year Anniversary - Looking Back And Moving Forward, Phyllis Braudy Harris, John Keady
Phyllis Braudy Harris
No abstract provided.
Another Wrinkle In The Debate About Successful Aging: The Undervalued Concept Of Resilience And The Lived Experience Of Dementia, Phyllis Harris
Another Wrinkle In The Debate About Successful Aging: The Undervalued Concept Of Resilience And The Lived Experience Of Dementia, Phyllis Harris
Phyllis Braudy Harris
The concept of "successful aging" is a contested discourse in gerontology. Two conflicting paradigms dominate the discussion: a health promotion activity model, and a model critical of the concept of successful aging. However, this study takes a different perspective and proposes that perhaps we have been striving for the wrong goal. The true quest as we age should not be for successful aging, but our goal should be for resilience, an undervalued and not fully examined concept in aging. Developing resilience is possible for many older adults regardless of social and cultural backgrounds or physical and cognitive impairments, unlike successful …
Family Matters, Phyllis Braudy Harris, John Keady
Family Matters, Phyllis Braudy Harris, John Keady
Phyllis Braudy Harris
No abstract provided.