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Full-Text Articles in Social and Behavioral Sciences
The Role Of Oral Microbiota In Periodontitis And Alzheimer's Disease, Noah Al-Hassan, Taha Al Hassan, Juan C. Lopez-Alvarenga, Maria Quinones, Seratna Guadarrama
The Role Of Oral Microbiota In Periodontitis And Alzheimer's Disease, Noah Al-Hassan, Taha Al Hassan, Juan C. Lopez-Alvarenga, Maria Quinones, Seratna Guadarrama
Research Symposium
Background: Periodontal disease (PD), affecting 20-50% of the global population is marked by biofilm-induced inflammation in oral tissues. Chronic PD results in systemic complications such as heart disease, stroke, and Alzheimer's. The red complex microbes, Porphyromonas gingivalis and Treponema denticola, play a pivotal role, penetrating the blood-brain barrier and contributing to neurodegeneration. Alzheimer's disease (AD), an irreversible neurodegenerative disorder, is linked to abnormal protein cleavage and potentially involves microbiologic components, including gram-positive cocci. Research suggests the presence of bacteria such as Porphyromonas, Actinomyces, and Treponema in autopsied AD brains. Investigating the microbiologic connection between PD and AD is crucial, considering …
A Study Protocol Testing Pre-Exposure Dose And Compound Pre-Exposure On The Mechanisms Of Latent Inhibition Of Dental Fear, Andrew L. Geers, Laura D. Seligman, Keenan A. Pituch, Ben Colagiuri, Hilary A. Marusak, Christine A. Rabinak, Natalie Turner, Sena L. Al-Ado, Michael Nedley
A Study Protocol Testing Pre-Exposure Dose And Compound Pre-Exposure On The Mechanisms Of Latent Inhibition Of Dental Fear, Andrew L. Geers, Laura D. Seligman, Keenan A. Pituch, Ben Colagiuri, Hilary A. Marusak, Christine A. Rabinak, Natalie Turner, Sena L. Al-Ado, Michael Nedley
Psychological Science Faculty Publications and Presentations
Background: Dental stimuli can evoke fear after being paired - or conditioned - with aversive outcomes (e.g., pain). Pre-exposing the stimuli before conditioning can impair dental fear learning via a phenomenon known as latent inhibition. Theory suggests changes in expected relevance and attention are two mechanisms responsible for latent inhibition. In the proposed research, we test whether pre-exposure dose and degree of pre-exposure novelty potentiate changes in expected relevance and attention to a pre-exposed stimulus. We also assess if the manipulations alter latent inhibition and explore the possible moderating role of individual differences in pain sensitivity.
Methods: Participants will be …