Social and Behavioral Sciences Commons^™

Personalized Depression Prevention: A Randomized Controlled Trial To Optimize Effects Through Risk-Informed Personalization, Jami F. Young, Jason D. Jones, Robert Gallop, Jessica S. Benas, Christie M. Schueler, Judy Garber, Benjamin L. Hankin

Mathematics Faculty Publications

Objective: To evaluate whether evidence-based depression prevention programs can be optimized by matching youths to interventions that address their psychosocial vulnerabilities. Method: This randomized controlled trial included 204 adolescents (mean [SD] age ¼ 14.26 [1.65] years; 56.4% female). Youths were categorized as high or low on cognitive and interpersonal risks for depression and randomly assigned to Coping With Stress (CWS), a cognitive-behavioral program, or Interpersonal Psychotherapy–Adolescent Skills Training (IPT-AST), an interpersonal program. Some participants received a match between risk and prevention (eg, high cognitive–low interpersonal risk teen in CWS, low cognitive–high interpersonal risk teen in IPT-AST), others received a mismatch …