Social and Behavioral Sciences Commons^™

Do Depressive Symptoms Mediate The Relationship Between Hopelessness And Diurnal Cortisol Rhythm?, Patrick Pössel, Amanda M. Mitchell, Elaine Sjögren, Margareta Kristenson

Faculty Scholarship

Purpose: Research has revealed a well-established relationship of depressive symptoms and hopelessness with a variety of physical illnesses that are associated with a dysfunction of the hypothalamic-pituitary-adrenal-axis. The purpose of this study was to test if depressive symptoms mediate the relationship between hopelessness and cortisol, a measure of the hypothalamic-pituitary-adrenal-axis. Methods: Hopelessness, depressive symptoms, and diurnal cortisol rhythm were measured in 257 adults (128 women and 129 men; age range: 20-74 years) in this cross-sectional study. To test the hypothesis, two linear regression analyses and asymmetrical confidence intervals around the regression weights were conducted. A second set of analyses was …