Social and Behavioral Sciences Commons^™

Hopelessness The ‘Active Ingredient’? : Associations Of Hopelessness And Depressive Symptoms With Interleukin-6., Amanda M. Mitchell, Patrick Pössel, Elaine Sjögren, Margareta Kristenson

Faculty Scholarship

Objective: Previous research has revealed a relationship of depressive symptoms and hopelessness with cardiovascular diseases (CVDs) which are associated with elevated levels of interleukin-6 (IL-6). The objective of this study was to explore whether depressive symptoms and hopelessness are independent predictors of IL-6 levels. Method: Hopelessness, depressive symptoms, and IL-6 were measured in 45 Swedish adults (26 women and 19 men; age range: 31-65 years). Two separated linear regressions were conducted with hopelessness and depressive symptoms serving as individual predictors of IL-6. Another regression analysis examined whether the two predictors predict IL-6 when controlling for each other. The regression coefficients …