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Acute Coronary Syndrome In Patients With Sars-Cov-2 Infection: Pathophysiology And Translational Perspectives, Francesco Paolo Cancro, Michele Bellino, Luca Esposito, Stefano Romei, Mario Centore, Debora D’Elia, Mario Cristiano, Angelantonio Maglio, Albino Carrizzo, Barbara Rasile, Carmine Alfano, Carmine Vecchione, Gennaro Galasso

Translational Medicine @ UniSa

Acute coronary syndromes (ACS) may complicate the clinical course of patients with Coronavirus Disease 2019 (COVID-19). It is still unclear whether this condition is a direct consequence of the primary disease. However, several mechanisms including direct cellular damage, endothelial dysfunction, in-situ thrombosis, systemic inflammatory response, and oxygen supply-demand imbalance have been described in patients with COVID-19. The onset of a prothrombotic state may also be facilitated by the endothelial dysfunction secondary to the systemic inflammatory response and to the direct viral cell damage. Moreover, dysfunctional endothelial cells may enhance vasospasm and platelet aggregation. The combination of these factors promotes atherosclerotic …