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Social and Behavioral Sciences Commons™
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Full-Text Articles in Social and Behavioral Sciences
In Search Of The Neurobiological Substrates For Social Playfulness In Mammalian Brains, Stephen M. Siviy, Jaak Panksepp
In Search Of The Neurobiological Substrates For Social Playfulness In Mammalian Brains, Stephen M. Siviy, Jaak Panksepp
Psychology Faculty Publications
Play behavior is a fundamental and intrinsic neurobehavioral process in the mammalian brain. Using rough-and-tumble play in the juvenile rat as a model system to study mammalian playfulness, some of the relevant neurobiological substrates for this behavior have been identified, and in this review this progress. A primary-process executive circuit for play in the rat that includes thalamic intralaminar nuclei, frontal cortex and striatum can be gleaned from these data. Other neural areas that may interact with this putative circuit include amygdala, ventral hypothalamus, periaqueductal gray (PAG), and deep tectum, as well as ascending dopamine systems which participate in all …
The Differential Effects Of Genetic And Dietary Alterations In Folate Status On Prefrontal Cortical Functions, Jessica Amanda Ash
The Differential Effects Of Genetic And Dietary Alterations In Folate Status On Prefrontal Cortical Functions, Jessica Amanda Ash
Legacy Theses & Dissertations (2009 - 2024)
Folate status plays an essential role in embryogenesis and brain development; however, its importance in supporting cognitive functioning throughout adulthood is less clear. The present study was interested in examining the effects of genetic and dietary alterations in folate status on prefrontal cortical functions in mice, modeling a common polymorphism in the MTHFD1 gene in folate metabolism. A factorial design was used crossing two genotypes (mice with a gene trap insertion in the Mthfd1 gene exhibiting 50% decreased Mthfd1 expression: Mthfd1gt/+ mice or wildtype mice) with two levels of dietary folate (folate sufficient or folate deficient). The mice were tested …