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Full-Text Articles in Social and Behavioral Sciences
Enhancing The Rewarding Effects And Subsequent Self-Administration Of Nicotine Through Appetitive Interoceptive Conditioning, Allissa Flynn
Enhancing The Rewarding Effects And Subsequent Self-Administration Of Nicotine Through Appetitive Interoceptive Conditioning, Allissa Flynn
Honors Theses
Nicotine is commonly considered to be the primary addictive constituent in tobacco products. Therefore, research focused on nicotine and its effects is necessary for understanding nicotine dependency and in developing potential cessation treatments. Research has confirmed the relevance of learning processes associated with nicotine and their influence on the development of addiction. Conditioning involving interoceptive stimuli is increasingly cited as playing a role in many diseases, psychopathologies, and drug addiction. The internal stimulus effects of nicotine can form associations with other reinforcing stimuli through a process of Pavlovian conditioning where nicotine is the conditioned stimulus. In this way, nicotine acquires …
Assessing A Two-Hit Model Of Schizophrenia: Prenatal Choline Deficiency And Induced Hypofunction Of Nmda Receptors In Male And Female Long Evans Rats, Samuel Gray, Samuel W. Gray
Assessing A Two-Hit Model Of Schizophrenia: Prenatal Choline Deficiency And Induced Hypofunction Of Nmda Receptors In Male And Female Long Evans Rats, Samuel Gray, Samuel W. Gray
Honors Theses
Choline is an essential dietary nutrient essential to the development and function of the central nervous system. Prenatal choline deficiency alters hippocampal development as well as acetylcholine metabolism, leading to cognitive impairments and attentional and sensory processing deficits into adulthood. MK-801 is an NMDA receptor antagonist frequently used in rodent models of neuropsychiatric conditions, particularly schizophrenia. Acutely and sub- chronically, it causes hyperlocomotion and social withdrawal. One primary goal of the present study were to investigate prenatal choline deficiency induces a biological vulnerability to the motor deficits, anhedonia, and social impairment precipitated by low-dose sub-chronic MK-801 administration in adulthood. Another …