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Social and Behavioral Sciences Commons™

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Biological Psychology

Department of Psychology: Faculty Publications

2014

Articles 1 - 5 of 5

Full-Text Articles in Social and Behavioral Sciences

Differential Effects Of Intermittent Versus Continuous Haloperidol Treatment Throughout Adolescence On Haloperidol Sensitization And Social Behavior In Adulthood, Jun Gao, Ming Li Oct 2014

Differential Effects Of Intermittent Versus Continuous Haloperidol Treatment Throughout Adolescence On Haloperidol Sensitization And Social Behavior In Adulthood, Jun Gao, Ming Li

Department of Psychology: Faculty Publications

Animal work on the behavioral effects of antipsychotic treatment suggests that different dosing regimens could affect drug sensitivity differently, with an intermittent treatment regimen tending to cause a sensitization effect, while a continuous treatment causing a tolerance. In this study, we explored how haloperidol (HAL) sensitization induced throughout adolescence and tested in adulthood was differentially impacted by these two dosing regimens in the conditioned avoidance response (CAR) test.We also examined howthese two dosing regiments affected social interaction and social memory in adulthood. Male adolescent Sprague-Dawley rats were treated with HAL via either osmotic minipump(HAL-0.25 CONT; 0.25mgkg−1 day−1, …

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Evolutionary Pressures On Primate Intertemporal Choice, Jeffrey R. Stevens May 2014

Evolutionary Pressures On Primate Intertemporal Choice, Jeffrey R. Stevens

Department of Psychology: Faculty Publications

From finding food to choosing mates, animals must make intertemporal choices that involve fitness benefits available at different times. Species vary dramatically in their willingness to wait for delayed rewards. Why does this variation across species exist? An adaptive approach to intertemporal choice suggests that time preferences should reflect the temporal problems faced in a species' environment. Here, I use phylogenetic regression to test whether allometric factors (relating to body size), relative brain size, and social group size predict how long 13 primate species will wait in laboratory intertemporal choice tasks. Controlling for phylogeny, a composite allometric factor that includes …

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Long-Lasting Sensitization Induced By Repeated Risperidone Treatment In Adolescent Sprague-Dawley Rats: A Possible D2 Receptor Mediated Phenomenon?, Jing Qiao, Jun Gao, Qing Shu, Qinglin Zhang, Gang Hu, Ming Li Apr 2014

Long-Lasting Sensitization Induced By Repeated Risperidone Treatment In Adolescent Sprague-Dawley Rats: A Possible D2 Receptor Mediated Phenomenon?, Jing Qiao, Jun Gao, Qing Shu, Qinglin Zhang, Gang Hu, Ming Li

Department of Psychology: Faculty Publications

Rationale Risperidone use in children and adolescents for the treatment of various neuropsychiatric disorders (e.g., schizophrenia, autism, disruptive behavior, etc.) has increased substantially in recent decades. However, its long-term effect on the brain and behavioral functions is not well understood. Objective The present study investigated how a short-term risperidone treatment in adolescence impacts antipsychotic response in adulthood in the conditioned avoidance response and phencyclidine (PCP)-induced hyperlocomotion tests. Methods Male adolescent Sprague-Dawley rats (postnatal days [P] 40–44 or 43–48) were first treated with risperidone (0.3, 0.5, or 1.0 mg/kg, subcutaneously (sc)) and tested in the conditioned avoidance or PCP (3.2 mg/kg, …

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Effects Of 5-Hydroxytryptamine 2c Receptor Agonist Mk212 And 2a Receptor Antagonist Mdl100907 On Maternal Behavior In Postpartum Female Rats, Weihai Chen, Qi Zhang, Wenxin Su, Yu Yang, Jing Qiao, Nan Sui, Ming Li Feb 2014

Effects Of 5-Hydroxytryptamine 2c Receptor Agonist Mk212 And 2a Receptor Antagonist Mdl100907 On Maternal Behavior In Postpartum Female Rats, Weihai Chen, Qi Zhang, Wenxin Su, Yu Yang, Jing Qiao, Nan Sui, Ming Li

Department of Psychology: Faculty Publications

Maternal behavior in rats is a highly motivated and well-organized social behavior. Given the known roles of serotonin (5-HT) in emotion, motivation, social behavior, and major depression – and its known interaction with dopamine – it is likely that serotonin also plays a crucial role in this behavior. So far, there are surprisingly few studies focusing on 5-HT in maternal behavior, except for maternal aggression. In the present study,we examined the effects of 5-HT2C receptor agonism and 5-HT2A receptor antagonism on maternal behavior in postpartum female rats.We hypothesized that activation of 5-HT2C receptors and blockade of 5-HT …

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Long-Term Impacts Of Adolescent Risperidone Treatment On Behavioral Responsiveness To Olanzapine And Clozapine In Adulthood, Jing Qiao, Qinglin Zhang, Ming Li Jan 2014

Long-Term Impacts Of Adolescent Risperidone Treatment On Behavioral Responsiveness To Olanzapine And Clozapine In Adulthood, Jing Qiao, Qinglin Zhang, Ming Li

Department of Psychology: Faculty Publications

This preclinical study investigated howa short-termrisperidone treatment in adolescence impacts antipsychotic response to olanzapine and clozapine in adulthood. Antipsychotic effect was indexed by a drug's suppressive effect on avoidance responding in a rat conditioned avoidance response (CAR) model. Male adolescent Sprague–Dawley rats were first treated with risperidone (1.0mg/kg, sc) or sterile water and tested in the CAR model for 5 consecutive days from postnatal days P 40 to 44. After they became adults (~P 80–84), they were switched to olanzapine (0.5mg/kg, sc), clozapine (5.0mg/kg, sc) or vehicle treatment and tested for avoidance for 5 days. During the adolescent period, repeated …

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