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Full-Text Articles in Social and Behavioral Sciences
Simvastatin Prevents Dopaminergic Neurodegeneration In Experimental Parkinsonian Models: The Association With Anti-Inflammatory Responses, Junqiang Yan, Yunqi Xu, Cansheng Zhu, Limin Zhang, Aimin Wu, Yu Yang, Zhaojun Xiong, Chao Deng, Xu-Feng Huang, Midori A. Yenari, Yuan-Guo Yang, Weihai Ying, Qing Wang
Simvastatin Prevents Dopaminergic Neurodegeneration In Experimental Parkinsonian Models: The Association With Anti-Inflammatory Responses, Junqiang Yan, Yunqi Xu, Cansheng Zhu, Limin Zhang, Aimin Wu, Yu Yang, Zhaojun Xiong, Chao Deng, Xu-Feng Huang, Midori A. Yenari, Yuan-Guo Yang, Weihai Ying, Qing Wang
Faculty of Health and Behavioural Sciences - Papers (Archive)
Background: In addition to their original applications to lowering cholesterol, statins display multiple neuroprotective effects. N-methyl-D-aspartate (NMDA) receptors interact closely with the dopaminergic system and are strongly implicated in therapeutic paradigms of Parkinson’s disease (PD). This study aims to investigate how simvastatin impacts on experimental parkinsonian models via regulating NMDA receptors. Methodology/Principal Findings: Regional changes in NMDA receptors in the rat brain and anxiolytic-like activity were examined after unilateral medial forebrain bundle lesion by 6-hydroxydopamine via a 3-week administration of simvastatin. NMDA receptor alterations in the post-mortem rat brain were detected by [3H]MK-801(Dizocilpine) binding autoradiography. 6-hydroxydopamine treated PC12 was applied …
Human Lens Lipids Differ Markedly From Those Of Commonly Used Experimental Animals, Jane Deeley, Todd W. Mitchell, Xiaojia Wei, Jurgen Korth, Jessica Hughes, Stephen J. Blanksby, Roger J. Truscott
Human Lens Lipids Differ Markedly From Those Of Commonly Used Experimental Animals, Jane Deeley, Todd W. Mitchell, Xiaojia Wei, Jurgen Korth, Jessica Hughes, Stephen J. Blanksby, Roger J. Truscott
Faculty of Health and Behavioural Sciences - Papers (Archive)
Electrospray ionisation tandem mass spectrometry has allowed the unambiguous identification andquantification of individual lens phospholipids in human and six animal models. Using this approach ca. 100unique phospholipids have been characterised. Parallel analysis of the same lens extracts by a novel directinsertionelectron-ionization technique found the cholesterol content of human lenses to be significantlyhigher (ca. 6 times) than lenses from the other animals.The most abundant phospholipids in all the lenses examined were choline-containing phospholipids. In rat,mouse, sheep, cow, pig and chicken, thesewere present largely as phosphatidylcholines, in contrast 66% of thetotal phospholipid in Homo sapienswas sphingomyelin, with the most abundant being dihydrosphingomyelins,in …
Jitter And Size Effects On Vection Are Immune To Experimental Instructions And Demands, Stephen A. Palmisano, Amy Y. Chan
Jitter And Size Effects On Vection Are Immune To Experimental Instructions And Demands, Stephen A. Palmisano, Amy Y. Chan
Faculty of Health and Behavioural Sciences - Papers (Archive)
Both coherent perspective jitter and explicit changing-size cues have been shown to improve the vection induced by radially expanding optic flow. The current study examined whether these stimulus-based vection advantages could be modified by altering cognitions/expectations about both the likelihood of self-motion perception and the purpose of the experiment. In the main experiment, participants were randomly assigned into two groups – one where the cognitive conditions biased participants towards self-motion perception and another where the cognitive conditions biased them towards object motion perception. Contrary to earlier findings by Lepecq et al (1995), we found that identical visual displays were less …