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Full-Text Articles in Social and Behavioral Sciences
Plasminogen Binding And Activation At The Breast Cancer Cell Surface: The Integral Role Of Urokinase Activity, Gillian E. Stillfried, Darren Saunders, Marie Ranson
Plasminogen Binding And Activation At The Breast Cancer Cell Surface: The Integral Role Of Urokinase Activity, Gillian E. Stillfried, Darren Saunders, Marie Ranson
Faculty of Health and Behavioural Sciences - Papers (Archive)
INTRODUCTION: The regulation of extracellular proteolytic activity via the plasminogen activation system is complex, involving numerous activators, inhibitors and receptors. Previous studies on monocytic and colon cell lines suggest that plasmin pre treatment can increase plasminogen binding, allowing the active enzyme to generate binding sites for its precursor. Other studies have shown the importance of pre formed receptors such as annexin II heterotetramer. However, few studies have utilised techniques which exclusively characterise cell surface events and these mechanisms have not been investigated at the breast cancer cell surface. METHODS: We have studied plasminogen binding to MCF 7 in which uPAR …
Arousal And Activation Effects On Physiological And Behavioral Responding During A Continuous Performance Task, Jacqueline A. Rushby, Robert J. Barry, Adam R. Clarke, Mohammad Vaezmousavi
Arousal And Activation Effects On Physiological And Behavioral Responding During A Continuous Performance Task, Jacqueline A. Rushby, Robert J. Barry, Adam R. Clarke, Mohammad Vaezmousavi
Faculty of Health and Behavioural Sciences - Papers (Archive)
Based on previous work indicating different neural substrates, two aspects of energetic state, arousal and activation, have been conceptualised separately in our laboratory. Arousal has been defined as the energetic state at any particular time, and task-related activation as the task-related change in state from resting baseline to the task situation. Both are reflected in electrodermal activity and measured by skin conductance level. Our previous studies in this area have indicated that physiological responses to stimuli in a task are dependent on the arousal level at the time of stimulus presentation, rather than the task-related activation. In contrast, performance on …