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Social and Behavioral Sciences Commons™
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Full-Text Articles in Social and Behavioral Sciences
Regaining Effort-Based Food Motivation: The Drug Methylphenidate Reverses The Depressive Effects Of Tetrabenazine In Female Rats, Deanna Pietrorazio
Regaining Effort-Based Food Motivation: The Drug Methylphenidate Reverses The Depressive Effects Of Tetrabenazine In Female Rats, Deanna Pietrorazio
Honors Scholar Theses
Tetrabenazine (TBZ), a vesicular monoamine transporter type 2 (VMAT-2) inhibitor, depletes dopamine and induces motivational deficits and other depressive symptoms in humans. Methylphenidate (MPH) is a dopamine transport blocker that is used to enhance motivational function. Previous studies have shown that in male rats, TBZ induces a shift in effort-related choice such that a low-effort bias is induced. In male rats this occurs at a dose range of 0.75-1.0 mg/kg TBZ, and this effect is reversible with co-administration of MPH. Recent studies have shown that females need a higher dose of TBZ (2.0 mg/kg) to show the low-effort bias. The …
Investigating The Impact Of Unlimited Sucrose During Adolescence On Flex Maze Performance In Rats, Emma Klopatek, Emily Tobolski, Bailey Harvey, Danielle Frances, Taylor Garrels, Gillian Lado
Investigating The Impact Of Unlimited Sucrose During Adolescence On Flex Maze Performance In Rats, Emma Klopatek, Emily Tobolski, Bailey Harvey, Danielle Frances, Taylor Garrels, Gillian Lado
Science University Research Symposium (SURS)
As depression continues to impact many people, there are important considerations to be taken in how depression impacts people's learning and motivations. The objective of this study is to examine the effects of unlimited sucrose consumption during adolescence, which can mimic symptoms of depression, on spatial memory and motivation in rats. The flex maze is used in the present study to assess these behaviors. Before initial training on the flex maze, 6 male rats were separated into two groups: an experimental group with unlimited access to 5% sucrose (and water) for approximately 3 weeks and a control group with free …