Open Access. Powered by Scholars. Published by Universities.®
Environmental Health and Protection Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Environmental Health and Protection
Beta Interferon-Mediated Activation Of Signal Transducer And Activator Of Transcription Protein 1 Interferes With Rickettsia Conorii Replication In Human Endothelial Cells, Punsiri M. Colonne, Marina Eremeeva, Sanjeev K. Sahni
Beta Interferon-Mediated Activation Of Signal Transducer And Activator Of Transcription Protein 1 Interferes With Rickettsia Conorii Replication In Human Endothelial Cells, Punsiri M. Colonne, Marina Eremeeva, Sanjeev K. Sahni
Marina E. Eremeeva
Infection of the endothelial cell lining of blood vessels with Rickettsia conorii, the causative agent of Mediterranean spotted fever, results in endothelial activation. We investigated the effects of R. conorii infection on the status of the Janus kinase (JAK)-signal transducer and activator of transcription protein (STAT) signaling pathway in human microvascular endothelial cells (HMECs), the most relevant host cell type, in light of rickettsial tropism for microvascular endothelium in vivo. R. conoriiinfection induced phosphorylation of STAT1 on tyrosine 701 and serine 727 at 24, 48, and 72 h postinfection in HMECs. Employing transcription profile analysis and neutralizing …