Physical Sciences and Mathematics Commons^™

Profiling A Community-Specific Function Landscape For Bacterial Peptides Through Protein-Level Meta-Assembly And Machine Learning, Mitra Vajjala, Brady Johnson, Lauren Kasparek, Michael Leuze, Qiuming Yao

School of Computing: Faculty Publications

Small proteins, encoded by small open reading frames, are only beginning to emerge with the current advancement of omics technology and bioinformatics. There is increasing evidence that small proteins play roles in diverse critical biological functions, such as adjusting cellular metabolism, regulating other protein activities, controlling cell cycles, and affecting disease physiology. In prokaryotes such as bacteria, the small proteins are largely unexplored for their sequence space and functional groups. For most bacterial species from a natural community, the sample cannot be easily isolated or cultured, and the bacterial peptides must be better characterized in a metagenomic manner. The bacterial …