Physical Sciences and Mathematics Commons^™

Deepnec: A Novel Alignment-Free Tool For The Characterization Of Nitrification-Related Enzymes Using Deep Learning, A Step Towards Comprehensive Understanding Of The Nitrogen Cycle, Naveen Duhan

Student Research Symposium

Abstract: Nitrification is an important microbial two-step transformation in the global nitrogen cycle, as it is the only natural process that produces nitrate within a system. The functional annotation of nitrification-related enzymes has a broad range of applications in metagenomics, agriculture, industrial biotechnology, etc. The time and resources needed for determining the function of enzymes experimentally are restrictively costly. Therefore, an accurate genome-scale computational prediction of the nitrification-related enzymes has become much more important.In this study, we developed an alignment-free computational approach to determine the nitrification-related enzymes from the sequence itself. We propose deepNEC, a novel end-to-end feature selection and …