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Full-Text Articles in Physical Sciences and Mathematics
Mathematical Modelling Of Prophage Dynamics, Tyler Pattenden
Mathematical Modelling Of Prophage Dynamics, Tyler Pattenden
Electronic Thesis and Dissertation Repository
We use mathematical models to study prophages, viral genetic sequences carried by bacterial genomes. In this work, we first examine the role that plasmid prophage play in the survival of de novo beneficial mutations for the associated temperate bacteriophage. Through the use of a life-history model, we determine that mutations first occurring in a plasmid prophage are far more likely to survive drift than those first occurring in a free phage. We then analyse the equilibria and stability of a system of ordinary differential equations that describe temperate phage-host dynamics. We elucidate conditions on dimensionless parameters to determine a parameter …
Innovative Approaches In The Discovery Of Aquatic Mycobacteriophages, Janis H. Doss
Innovative Approaches In The Discovery Of Aquatic Mycobacteriophages, Janis H. Doss
Biomedical Sciences Theses & Dissertations
Bacteriophages (phages), viruses that infect bacteria, have many applications in medicine, agriculture, molecular biology, and other fields. As antibiotic resistance becomes an increasing problem, interest in phages has grown. The traditional techniques of phage discovery are successful for some phages, but others require modified procedures to achieve detectable host infection.
Mycobacterium is a diverse bacterial genus characterized by a unique cell wall containing mycolic acids, which aids in survival and pathogenesis. The aims of the present research were to isolate mycobacteriophages, use bioinformatics techniques to analyze mycobacterial prophages, and combine genetic analysis with multi-well plate host range studies to identify …