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Full-Text Articles in Physical Sciences and Mathematics
A Direct, Early Stage Guanidinylation Protocol For The Synthesis Of Complex Aminoguanidine-Containing Natural Products, Christopher E. Malmberg, Stephen Chamberland
A Direct, Early Stage Guanidinylation Protocol For The Synthesis Of Complex Aminoguanidine-Containing Natural Products, Christopher E. Malmberg, Stephen Chamberland
All Faculty Scholarship for the College of the Sciences
The guanidine functional group, displayed most prominently in the amino acid arginine, one of the fundamental building blocks of life, is an important structural element found in many complex natural products and pharmaceuticals. Owing to the continual discovery of new guanidinecontaining natural products and designed small molecules, rapid and efficient guanidinylation methods are of keen interest to synthetic and medicinal organic chemists. Because the nucleophilicity and basicity of guanidines can affect subsequent chemical transformations, traditional, indirect guanidinylation is typically pursued. Indirect methods commonly employ multiple protection steps involving a latent amine precursor, such as an azide, phthalimide, or carbamate. By …
Kinetic Decay Of A Polymer/Ink Complex As An O2 Indicator, Becca Hoene
Kinetic Decay Of A Polymer/Ink Complex As An O2 Indicator, Becca Hoene
All Master's Theses
Indicator inks are an important part of the continued consumption of packaged goods. This thesis is focused on understanding the kinetics and reaction mechanism for a unique indicator ink that is based upon the oxidation of indigotetrasulfonate (ITS) encapsulated in the polyelectrolyte poly(diallyldimethylammonium chloride) (polyDADMAC). Sodium bisulfite (NaHSO3) was used as the initial oxygen scavenger and to drive the reduction of the ITS. Studies were predominantly done in solution phase through the dilution of the ink systems. Fluorescence spectroscopy was the primary method used to determine the kinetic decay rates and interaction between the ITS dye molecules and …