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Cdk8 And Cdk19 As Novel Regulators Of Bmp4 Induced Emt In Cancer, Anne Elizabeth Serrao
Cdk8 And Cdk19 As Novel Regulators Of Bmp4 Induced Emt In Cancer, Anne Elizabeth Serrao
Theses and Dissertations
Bone morphogenetic protein 2/4 (BMP2/4), members of the transforming growth factor β (Tgf-β) superfamily, play a dichotomous role in the progression of cancers through cell growth suppression and the enhancement of tumorigenesis in a variety of cancers. Cyclin dependent kinase 8 (CDK8), a protein kinase that regulates gene transcription, is involved in a variety of cancers including breast and pancreatic cancers as well as in mediating BMP2 signaling via its canonical Smad1 pathway. Our studies show that BMP4 induced EMT signals primarily though Smad1 and that Yap1, a transcriptional co-activator, is necessary for BMP4 induced EMT. Using a highly specific …