Physical Sciences and Mathematics Commons^™

Test On Existence Of Histology Subtype-Specific Prognostic Signatures Among Early Stage Lung Adenocarcinoma And Squamous Cell Carcinoma Patients Using A Cox-Model Based Filter, Suyan Tian, Chi Wang, Ming-Wen An

Biostatistics Faculty Publications

BACKGROUND: Non-small cell lung cancer (NSCLC) is the predominant histological type of lung cancer, accounting for up to 85% of cases. Disease stage is commonly used to determine adjuvant treatment eligibility of NSCLC patients, however, it is an imprecise predictor of the prognosis of an individual patient. Currently, many researchers resort to microarray technology for identifying relevant genetic prognostic markers, with particular attention on trimming or extending a Cox regression model. Adenocarcinoma (AC) and squamous cell carcinoma (SCC) are two major histology subtypes of NSCLC. It has been demonstrated that fundamental differences exist in their underlying mechanisms, which motivated us …