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Full-Text Articles in Physical Sciences and Mathematics
Comparison Of The Crystal Structures Of 4,4′-Bis[3-(4-MethylPiperidin-1-Yl)Prop-1-Yn-1-Yl]-1,1′-BiPhenyl And 4,4′-Bis[3-(2,2,6,6-TetraMethylPiperidin-1-Yl)Prop-1-Yn-1-Yl]-1,1′-BiphenYl, Anqi Wan, Narsimha Reddy Penthala, E. Kim Fifer, Sean Parkin, Peter A. Crooks
Comparison Of The Crystal Structures Of 4,4′-Bis[3-(4-MethylPiperidin-1-Yl)Prop-1-Yn-1-Yl]-1,1′-BiPhenyl And 4,4′-Bis[3-(2,2,6,6-TetraMethylPiperidin-1-Yl)Prop-1-Yn-1-Yl]-1,1′-BiphenYl, Anqi Wan, Narsimha Reddy Penthala, E. Kim Fifer, Sean Parkin, Peter A. Crooks
Chemistry Faculty Publications
As part of a comprehensive program to discover α9α10 nicotinic acetylcholine receptor antagonists, the title compounds C30H36N2, (I), and C36H48N2, (II), were synthesized by coupling 4,4′-bis(3-bromoprop-1-yn-1-yl)-1,1′-biphenyl with 4-methylpiperidine and 2,2,6,6-tetramethylpiperidine, respectively, in acetonitrile at room temperature. In compound (I), the biphenyl system has a twisted conformation with a dihedral angle of 26.57 (6)° between the two phenyl rings of the biphenyl moiety, while in compound (II), the biphenyl moiety sits on a crystallographic inversion centre so the two phenyl rings are exactly coplanar. The terminal piperidine rings in …
Comparison Crystal Structure Conformations Of Two Structurally Related Biphenyl Analogues: 4,4'-Bis[3-(Pyrrolidin-1-Yl)Prop-1-Yn-1-Yl]-1,1'-Biphenyl And 4,4'-Bis{3-[(S)-2-Methylpyrrolidin-1-Yl]Prop-1-Yn-1-Yl}-1,1'-Biphenyl, Anqi Wan, Narsimha Reddy Penthala, E. Kim Fifer, Sean Parkin, Peter A. Crooks
Comparison Crystal Structure Conformations Of Two Structurally Related Biphenyl Analogues: 4,4'-Bis[3-(Pyrrolidin-1-Yl)Prop-1-Yn-1-Yl]-1,1'-Biphenyl And 4,4'-Bis{3-[(S)-2-Methylpyrrolidin-1-Yl]Prop-1-Yn-1-Yl}-1,1'-Biphenyl, Anqi Wan, Narsimha Reddy Penthala, E. Kim Fifer, Sean Parkin, Peter A. Crooks
Chemistry Faculty Publications
The title compounds, C26H28N2, (I), and C28H32N2, (II), were designed based on the structure of the potent 910 nicotinic acetylcholine receptor antagonist ZZ161C {1,1'-[[1,1'-biphenyl]-4,4'-diylbis(prop-2-yne-3,1-diyl)]bis(3,4-dimethylpyridin-1-ium) bromide}. In order to improve the druglikeness properties of ZZ161C for potential oral administration, the title compounds (I) and (II) were prepared by coupling 4,4'-bis(3-bromoprop-1-yn-1-yl)-1,1'-biphenyl with pyrrolidine, (I), and (S)-2-methylpyrrolidine, (II), respectively, in acetonitrile at room temperature. The asymmetric unit of (I) contains two half molecules that each sit on sites of crystallographic inversion. As a result, the biphenyl ring systems in …