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- Keyword
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- (bio)degradable polymeric nanoparticles (1)
- Aerosols (1)
- Autoradiography (1)
- Biodistribution (1)
- Carbazole; Dimer; Anti/gauche conformation (1)
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- Escherichia coli (1)
- Functional polymeric nanoparticles (1)
- In vitro antimicrobial efficacy (1)
- Nanoparticle-based antimicrobial delivery system (1)
- Nanoparticles (1)
- Nose-only inhalation (1)
- Pharmacokinetics (1)
- Radiotracer (1)
- Silver antimicrobials (1)
- Silver carbene complexes (1)
- Staphylococcus aureus (1)
- THIN-LAYER CHROMATOGRAPHY; X-RAY CRYSTAL; MOLECULAR-STRUCTURE; PHOSPHONITRILIC DERIVATIVES; CYCLIC PHOSPHAZENES; PHOSPHORUS-PENTACHLORIDE; CHLORO-CYCLOPHOSPHAZENES; ELECTRONIC-STRUCTURE; PHYSICAL-PROPERTIES; MASS-SPECTROMETRY (1)
Articles 1 - 4 of 4
Full-Text Articles in Physical Sciences and Mathematics
Structure And Conformation Of The Medium-Sized Chlorophosphazene Rings, Bowers, David Bowers, Brian Wright, Vincenzo Scionti, Anthony Schultz, Matthew Panzner, Eric Twum, Lin-Lin Li, Bryan Katzenmeyer, Benjamin Thome, Peter Rinaldi, Chrys Wesdemiotis, Wiley Youngs, Claire Tessier
Structure And Conformation Of The Medium-Sized Chlorophosphazene Rings, Bowers, David Bowers, Brian Wright, Vincenzo Scionti, Anthony Schultz, Matthew Panzner, Eric Twum, Lin-Lin Li, Bryan Katzenmeyer, Benjamin Thome, Peter Rinaldi, Chrys Wesdemiotis, Wiley Youngs, Claire Tessier
Wiley J. Youngs
No abstract provided.
Structure And Conformation Of Meso-2,4-Di(N-Carbazolyl)Pentane, Patrick Wagers, Wiley Youngs, Aditya Agrahari, Steven Schildcrout, John Masnovi
Structure And Conformation Of Meso-2,4-Di(N-Carbazolyl)Pentane, Patrick Wagers, Wiley Youngs, Aditya Agrahari, Steven Schildcrout, John Masnovi
Wiley J. Youngs
The stereochemistry of the title compound is established as meso. The carbazole groups have no parallel planar close contacts (π-type interactions), which differs from the packing found previously for terminal 1,n-di(N-carbazolyl)alkanes. Bond distances, bond angles, and torsion angles are compared with those calculated for the isolated molecule using M06-2X density functional theory, which is designed to model intramolecular dispersion effects. The results indicate that dispersion effects have a significant influence on the molecular conformation, although packing effects likely determine the magnitude of the puckering about one of the nitrogens (N1) and give a crystal conformation …
Investigating The Pharmacokinetics And Biological Distribution Of Silver-Loaded Polyphosphoester-Based Nanoparticles Using 111ag As A Radiotracer, Tolulope Aweda, Shiyi Zhang, Chiedza Mupanomunda, Jennifer Burkemper, Gyu Heo, Nilantha Bandara, Mai Lin, Cathy Cutler, Carolyn Cannon, Wiley Youngs, Karen Wooley, Suzanne Lapi
Investigating The Pharmacokinetics And Biological Distribution Of Silver-Loaded Polyphosphoester-Based Nanoparticles Using 111ag As A Radiotracer, Tolulope Aweda, Shiyi Zhang, Chiedza Mupanomunda, Jennifer Burkemper, Gyu Heo, Nilantha Bandara, Mai Lin, Cathy Cutler, Carolyn Cannon, Wiley Youngs, Karen Wooley, Suzanne Lapi
Wiley J. Youngs
Purified 111Ag was used as a radiotracer to investigate silver loading and release, pharmacokinetics, and biodistribution of polyphosphoester-based degradable shell crosslinked knedel-like (SCK) nanoparticles as a comparison to the previously reported small molecule, N-heterocyclic silver carbene complex analog (SCC1) for the delivery of therapeutic silver ions in mouse models. Biodistribution studies were conducted by aerosol administration of 111Ag acetate, [111Ag]SCC1, and [111Ag]SCK doses directly into the lungs of C57BL/6 mice. Nebulization of the 111Ag antimicrobials resulted in an average uptake of 1.07 ± 0.12% of the total aerosolized dose given per mouse. The average dose taken into the lungs of …
Preparation And In Vitro Antimicrobial Activity Of Silver-Bearing Degradable Polymeric Nanoparticles Of Polyphosphoester-Block-Poly(L-Lactide), Young Lim, Kristin Tiemann, Gyu Heo, Patrick Wager, Yohannes Rezenom, Shiyi Zhang, Fuwu Zhang, Wiley Youngs, David Hunstad, Karen Wooley
Preparation And In Vitro Antimicrobial Activity Of Silver-Bearing Degradable Polymeric Nanoparticles Of Polyphosphoester-Block-Poly(L-Lactide), Young Lim, Kristin Tiemann, Gyu Heo, Patrick Wager, Yohannes Rezenom, Shiyi Zhang, Fuwu Zhang, Wiley Youngs, David Hunstad, Karen Wooley
Wiley J. Youngs
The development of well-defined polymeric nanoparticles (NPs) as delivery carriers for antimicrobials targeting human infectious diseases requires rational design of the polymer template, an efficient synthetic approach, and fundamental understanding of the developed NPs, e.g., drug loading/release, particle stability, and other characteristics. Herein, we developed and evaluated the in vitro antimicrobial activity of silver-bearing, fully biodegradable and functional polymeric NPs. A series of degradable polymeric nanoparticles (dNPs), composed of phosphoester and l-lactide and designed specifically for silver loading into the hydrophilic shell and/or the hydrophobic core, were prepared as potential delivery carriers for three different types of silver-based antimicrobials–silver acetate …