Physical Sciences and Mathematics Commons^™

Diffractive Optical Elements With A Large Angle Of Operation Recorded In Acrylamide Based Photopolymer On Flexible Substrates, Hoda Akbari, Izabela Naydenova, Lina Persechini, Sean Garner, Pat Cimo, Suzanne Martin

Articles

A holographic device characterised by a large angular range of operation is under development. The aim of this study is to increase the angular working range of the diffractive lens by stacking three layers of high efficiency optical elements on top of each other so that light is collected (and focussed) from a broader range of angles. The angular range of each individual lens element is important, and work has already been done in an acrylamide-based photosensitive polymer to broaden the angular range of individual elements using holographic recording at a low spatial frequency.This paper reports new results on the …

Antimicrobial Properties Of Nano-Silver: A Cautionary Approach To Ionic Interference, Kate Sheehy, Alan Casey, Anna Murphy, Gordon Chambers

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Hypothesis: Metallic nanoparticles such as nano-silver have found many applications as alternative antimicrobials in recent years. However methods for determining their proposed antimicrobial activity have received little attention to date. The disk diffusion assay is commonly used as a demonstration of antimicrobial properties and is a regular feature in synthetic nanoparticle papers. The aim of this study was to assess its effectiveness in demonstrating the ‘‘nanoparticle specific’’ antimicrobial properties in the absence of ionic contributions from unreacted reducing agents and or impurities. Experiments: The disk diffusion assay was carried out on a range of silver nanoparticles, both in-house synthesised and …

Competitive Evaluation Of Data Mining Algorithms For Use In Cassification Of Leukocyte Subtypes With Raman Microspectroscopy, Adrian Maguire, I. Vega-Carrascal, Jane Bryant, Lisa White, Orla Howe, Fiona Lyng, Aidan Meade

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Raman microspectroscopy has been investigated for some time for use in label-free cell sorting devices. These approaches require coupling of the Raman spectrometer to complex data mining algorithms for identification of cellular subtypes such as the leukocyte subpopulations of lymphocytes and monocytes. In this study, three distinct multivariate classification approaches, (PCA-LDA, SVMs and Random Forests) are developed and tested on their ability to classify the cellular subtype in extracted peripheral blood mononuclear cells (T-cell lymphocytes from myeloid cells), and are evaluated in terms of their respective classification performance. A strategy for optimisation of each of the classification algorithm is presented …

Raman Microspectroscopy For The Early Detection Of Pre-Malignant Changes In Cervical Tissue, Nosheen Rashid, Haq Nawaz, Kelvin W. Poon, Franck Bonnier, Salih Bakhiet, Cara Martin, John O'Leary, Hugh Byrne, Fiona Lyng

Articles

Cervical cancer is the third most common cancer affecting women worldwide. The mortality associated with cervical cancer can, however, be significantly reduced if the disease is detected at the pre-malignant stage. The aim of this study was to evaluate the potential of Raman microspectroscopy for elucidation of the biochemical changes associated with the pre-malignant stages of cervical cancer. Formalin fixed paraffin preserved tissue sections from cervical biopsies classified as negative for intraepithelial lesion and malignancy (NILM), low grade squamous intraepithelial lesion (LSIL) or high grade squamous intraepithelial lesion (HSIL) were analysed by Raman spectral mapping. Raman mapping, with K-Means Cluster …

Quantitative Assessment Of Blood Coagulation By Cold Atmospheric Plasma, Caitlin Heslin, Daniela Boehm, Vladimir Milosavljevic, Michelle Laycock, Patrick Cullen, Paula Bourke

Articles

Cold atmospheric plasma (CAP) is produced by ionizing a chosen gas, thereby creating charged and reactive species. The reactive species generated are capable of inducing a range of biomedically relevant interactions including blood coagulation. However, the underlying biochemical processes of plasma-assisted blood coagulation are largely unknown, and data quantifying blood clot formation or the impact of system parameters on the intensity of the blood clot are scarce. In this study, blood coagulation was quantified by measuring hemoglobin absorbance. System parameters of the kINPen plasma jet were investigated and compared, including treatment time, distance from the plasma source and gas flow …

A Soft Condensed Matter Approach Towards Mathematical Modelling Of Mass Transport And Swelling In Food Grains, Michael Chapwanya, N. Misra

Articles

Soft condensed matter (SCM) physics has recently gained importance for a large class of engineering materials. The treatment of food materials from a soft matter perspective, however, is only at the surface and is gaining importance for understanding the complex phenomena and structure of foods. In this work, we present a theoretical treatment of navy beans from a SCM perspective to describe the hydration kinetics. We solve the transport equations within a porous matrix and employ the Flory–Huggin’s equation for polymer–solvent mixture to balance the osmotic pressure. The swelling of the legume seed is modelled as a moving boundary with …

One-Dimensional Weakly Nonlinear Model Equations For Rossby Waves, David Henry, Rossen Ivanov

Articles

In this study we explore several possibilities for modelling weakly nonlinear Rossby waves in fluid of constant depth, which propagate predominantly in one direction. The model equations obtained include the BBM equation, as well as the integrable KdV and Degasperis-Procesi equations.

Slow Plastic Creep Of 2d Dusty Plasma Solids, Angela Douglass, Peter Hartmann, Aniko Zs. Kovacs, Jorge C. Reyes, Lorin S. Matthews, Truell W. Hyde

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We report complex plasma experiments, assisted by numerical simulations, providing an alternative qualitative link between the macroscopic response of polycrystalline solid matter to small shearing forces and the possible underlying microscopic processes. In the stationary creep regime we have determined the exponents of the shear rate dependence of the shear stress and defect density. We show that the formation and rapid glide motion of dislocation pairs in the lattice are dominant processes.

Microfiber Coupler Based Label-Free Immunosensor, Lin Bo, Christy Charlton O'Mahony, Yuliya Semenova, Niamh Gilmartin, Pengfei Wang, Gerald Farrell

Articles

Optical microfibers and related structures which incorporate large evanescent field and minimal size offer new opportunities for biosensing applications. In this paper we report the development of an immunosensor based on a tapered microfiber coupler embedded in a low refractive index polymer. Biomolecules adsorbed on the microfiber coupler surface modify the surrounding refractive index. By immobilizing antigens on the surface of the sensing area, the microfiber coupler was able to operate as a label-free immunosensor to detect specific antibodies. We experimentally demonstrated for the first time the sensing ability of this sensor using a fibrinogen antigen-antibody pair. By monitoring the …

Improved Protocols For Vibrational Spectroscopic Analysis Of Body Fluids, Franck Bonnier, François Petitjean, Matthew Baker, Hugh Byrne

Articles

The applications of vibrational spectroscopy to the examination of human blood serum are explored. Although FTIR spectra can be recorded in aqueous solutions at (gelatin) concentrations as low as 100mg/L, the high-wavenumber region remains obscured by water absorption. Using Raman spectroscopy, high quality spectra of gelatine solutions as low as 10mg/L can be achieved, also covering the high-wavenumber regions. In human serum, spectral profiles are weak and partially obscured by water features. Dried deposits are shown to be physically and chemically inhomogeneous resulting in reduced measurement reproducibility. Concentration of the serum using commercially available centrifugal filter devices results in an …

In-Package Atmospheric Pressure Cold Plasma Treatment Of Cherry Tomatoes, N. Misra, Kevin Keener, Paula Bourke, J Mosnier, Patrick Cullen

Articles

Cold plasma is increasingly under research for decontamination of foods, especially fresh fruits and vegetables. The effect of cold plasma on food quality, however, remains under researched. This study investigates the effects of cold plasma generated within a sealed package from a dielectric barrier discharge on the physical quality parameters and respiration rates of cherry tomatoes. Respiration rates and weight loss were monitored continuously, while other parameters are reported at the end of storage period. Differences among weight loss, pH and firmness for control and treated cherry tomatoes were insignificant towards the end of storage life. Changes in respiration rates …

In-Package Atmospheric Pressure Cold Plasma Treatment Of Strawberries, N. Misra, Paula Bourke, Patrick Cullen, Sonal Patil

Articles

The ability to generate low temperature plasma at atmospheric pressure offers new opportunities to decontaminate biological materials, including fresh foods. In this study, strawberries were treated with atmospheric cold plasma (ACP), generated with a 60 kV dielectric barrier discharge (DBD) pulsed at 50 Hz, across a 40 mm electrode gap, generated inside a sealed package containing ambient air (42% relative humidity). The current-voltage characteristics revealed that the plasma operated in the filamentary regime. The background microflora (aerobic mesophillic bacteria, yeast and mould) of strawberries treated for 5 min was reduced by 2 log 10 within 24 h of post-ACP treatment. …

Using Acrylamide Based Photopolymers For Fabrication Of Holographic Optical Elements In Solar Energy Applications, Hoda Akbari, Izabela Naydenova, Suzanne Martin

Articles

A holographic device is under development that aims to improve light collection in solar cells. The aim is to explore the potential of using photopolymer Holographic Optical Elements (HOE) to collect light from a moving source, such as the sun, and re-direct it for concentration by a holographic lens.. A working range of 45 degrees is targeted for such a device to be useful in solar applications without tracking. A photopolymer HOE is capable of efficiently re-directing light, but the angular selectivity of a single grating is usually of the order of one degree at the thicknesses required for high …

In-Package Nonthermal Plasma Degradation Of Pesticides On Fresh Produce, N. Misra, Shashi Pankaj, Tony Walsh, Finbarr O'Regan, Paula Bourke, Patrick Cullen

Articles

In-package nonthermal plasma (NTP) technology is a novel technology for the decontamination of foods and biological materials. This study presents the first report on the potential of the technology for the degradation of pesticide residues. A cocktail of pesticides, namely Azoxystrobin, Cyprodinil, Fludioxonil and Pyriproxyfen was tested on strawberries. The concentrations of these pesticides were monitored in priori and post- plasma treatment using GC-MS/MS. An applied voltage and time dependent degradation of the pesticides was observed for treatment voltages of 60, 70 and 80 kV and treatment durations ranging from 1 to 5 min, followed by 24 h in-pack storage. …

Vibrational Spectroscopic Analysis Of Body Fluids: Avoiding Molecular Contamination Using Centrifugal Filtration, Franck Bonnier, Matthew Baker, Hugh Byrne

Articles

The use of centrifugal filtration for protein purification and concentration represents an important improvement for the application of vibrational spectroscopy to analysis of bodily fluids based on protein fractions with specific molecular weight. Vibrational spectroscopic techniques are highly specific and can potentially detect small variations in the protein content indicating the presence of different diseases, therefore usable as markers for early diagnostic. However, due to the high sensitivity of the techniques, it is essential to verify that no molecular contamination occurs during the preparation of the samples. Concentration of the blood serum using commercially available centrifugal filters has been shown …

A Photonic Crystal Fiber Based Polarimetric Sensor For Cure Monitoring Of Magneto-Rheological Smart Composite Material, Manjusha Ramakrishnan, Ginu Rajan, Yuliya Semenova, Y. Zhou, Stephen Jerrams, Gerald Farrell

Articles

A buffer stripped high birefringent photonic crystal fibre based polarimetric sensor is developed for monitoring the curing process of magnetorheological elastomer (MRE) smart composite material. Using the developed sensor, different phases of the MRE curing process are clearly visible from the phase shift variation of the embedded polarisation maintaining photonic crystal fibre (PM-PCF) sensor. During the curing process, the buffer stripped PM-PCF exhibits a stress/strain induced phase shift variation from 0 to 1.98 rad. This is a significantly large phase change, which can be used to very clearly identify the different stages in the curing process. For comparison, a fibre …

Experimental Study And Analysis Of A Polymer Fiber Bragg Grating Embedded In A Composite Material, Ginu Rajan, Manjusha Ramakrishnan, Yuliya Semenova, Eliathamby Ambikairajah, Gerald Farrell, Gang-Ding Peng

Articles

The characteristics of polymer fiber Bragg gratings (FBGs) embedded in composite materials are studied in this paper and are compared with characteristics of their silica counterparts. A polymer FBG of 10 mm length which exhibits a peak reflected wavelength circa 1530 nm is fabricated and characterized for this purpose. A silica FBG with a peak reflected wavelength circa 1553 nm is also embedded in the composite material for a comparison study. The fabricated composite material sample with embedded sensors is subjected to temperature and strain changes and the corresponding effects on the embedded polymer and silica FBGs are studied. The …

Suppression Of Raman Soliton Self-Frequency Shift In Photonic Cystal Fibers With Tellurite Subwavelength Core, Shua Wei, Jinhui Yuan, Chongxiu Yu, Sha Li, Boyuan Jin, Xiaoming Hu, Gerald Farrell, Qiang Wu

Articles

A new nonlinear evolution equation including the vector nature of the electromagnetic field and the frequency variation of the mode profile is derived. A kind of new nonlinearity is demonstrated. Its magnitude is strongly dependent on the waveguide geometrical parameters, which will lead to a suppression of the Raman soliton self-frequency shift in a photonic crystal fiber with a tellurite subwavelength core. Our results can be supported by the detailed numerical simulations

Economic Valuation Of The Mortality Benefits Of A Regulation On So2 In 20 European Cities, Olivier Chanel, Susann Henschel, Patrick J. Goodman, Antonis Analitis, Richard W. Atkinson, Alain Le Tertre, Ariana Zeka, Sylivia Medina

Articles

Background: Since the 1970s, legislation has led to progress in tackling several air pollutants. We quantify the annual monetary benefits resulting from reductions in mortality from the year 2000 onwards following the implementation of three European Commission regulations to reduce the sulphur content in liquid fuels for vehicles. Methods: We first compute premature deaths attributable to these implementations for 20 European cities in the Aphekom project by using a two-stage health impact assessment method. We then justify our choice to only consider mortality effects as short-term effects. We rely on European studies when selecting the central value of …

Investigation Of The Sensitivity To Humidity Of An Acrylamide-Based Photopolymer Containing N-Phenylglycine As A Photoinitiator, Tatsiana Mikulchyk, Suzanne Martin, Izabela Naydenova

Articles

Sensitivity of holographic recording materials to the relative humidity (RH) of the environment often restricts their use in fabrication of holographic optical elements and other applications. It is important to develop materials with little or no sensitivity to humidity. In this paper the humidity response of transmission gratings recorded in an acrylamide-based photopolymer containing N-phenylglycine (NPG) as a photoinitiator is studied at RH = 20 – 90 %. The hologram is found to be completely insensitive to humidity at RH below 70 % and its diffraction efficiency remains constant. A decrease in diffraction efficiency is observed at RH = 80 …

Photonic Crystal Fiber Half-Taper Probe Based Refractometer, Pengfei Wang, Ming Ding, Lin Bo, Chunying Guan, Yuliya Semenova, Weimin Sun, Libo Yuan, Gilberto Brambilla, Gerald Farrell

Articles

A compact singlemode - photonic crystal fibre - singlemode fibre tip (SPST) refractive index sensor is demonstrated in this paper. A CO₂ laser cleaving technique is utilsed to provide a clean-cut fibre tip which is then coated by a layer of gold to increase reflection. An average sensitivity of 39.1 nm/RIU and a resolvable index change of 2.56×10^-4 are obtained experimentally with a ~3.2 µm diameter SPST. The temperature dependence of this fiber optic sensor probe is presented. The proposed SPST refractometer is also significantly less sensitive to temperature and an experimental demonstration of this reduced sensitivity is …

Diagnostics Of An O2–He Rf Atmospheric Plasma Discharge By Spectral Emission, Vladimir Milosavljevic, Mick Donegan, Patrick Cullen, Denis Dowling

Articles

In this paper optical emission spectroscopy (OES) is used as a Diagnostic technique for the measurement of atomic and molecular spectral emissions generated using a helium rf industrial atmospheric plasma jet system. The OES of neutral atomic spectral lines and molecular bands are investigated over a range of plasma process parameters.
Wavelength resolve optical emission profiles suggest that the emission of helium’s spectral lines shows that the high energy electrons have a larger influence than helium metastables on the overall spectral emission. Furthermore, the experimental data indicates that the use of high helium flow rates, in any confined open air …

Getting Started With Research "Carrying Out Your Research Project", Jacinta Browne

Articles

This paper gives an overview of the considerations and practical aspects of carrying out a research project which may be of use to those beginning their research career or simply carrying out a research project for the first time as part of an academic qualification. It outlines practical steps for consideration in the day to day management of a research project and highlights areas which require particular consideration for a project to be completed successfully.

An Audit Of A Hospital-Based Doppler Ultrasound Quality Control Protocol Using A Commercial String Doppler Phantom, S. Cournane, A. J. Fagan, Jacinta Browne

Articles

Results from a four-year audit of a Doppler quality assurance (QA) program using a commercially available Doppler string phantom are presented. The suitability of the phantom was firstly determined and modifications were made to improve the reliability and quality of the measurements. QA of Doppler ultrasound equipment is very important as data obtained from these systems is used in patient management. It was found that if the braided-silk filament of the Doppler phantom was exchanged with an O-ring rubber filament and the velocity range below 50cm/s was avoided for Doppler quality control (QC) measurements, then the Maximum Velocity Accuracy (MVA) …

A Review Of Doppler Ultrasound Quality Assurance Protocols And Test Devices, Jacinta Browne

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In this paper, an overview of Doppler ultrasound quality assurance (QA) testing will be presented in three sections. The first section will review the different Doppler ultrasound parameters recommended by professional bodies for use in QA protocols. The second section will include an evaluation and critique of the main test devices used to assess Doppler performance, while the final section of this paper will discuss which of the wide range of test devices have been found to be most suitable for inclusion in Doppler QA programmes. Pulsed Wave Spectral Doppler, Colour Doppler Imaging QA test protocols have been recommended over …

Holographic Sensors: Three-Dimensional Analyte-Sensitive Nanostructures And Their Applications, Ali K. Yetisen, Izabela Naydenova, Fernando Da Cruz Vasconcellos, Jeffrey Blyth, Christopher R. R. Lowe

Articles

Holographic sensors are analytical devices that systematically diffract narrow-band light in the ultraviolet to near-infrared range for application in the detection and quantification of analytes and/or physical parameters. They can be functionalized with analyte-responsive materials to construct highly sensitive optical sensors for use in testing, where a visual readout, fast turnaround time, and reversibility are needed. Holography allows fabrication of disposable sensors that are lightweight for miniaturization and multiplexing purposes.3 Holographic sensors offer three capabilities on a single analytical device: (i) label-free analyte-responsive polymer, (ii) real-time, reversible quantification of the external stimuli, and (iii) three-dimensional visual image display.

The Utility Of Deformable Image Registration For Small Artery Visualisation In Contrast-Enhanced Whole Body Mr Angiography, Daniel Foley, Jacinta Browne, Xiahai Zhuang, Barry Sheane, Dearbhail O'Driscoll, Daniel Cannon, Niall Sheehy, James Meaney, Andrew Fagan

Articles

Purpose;

An investigation was carried out into the effect of three image registration techniques on the diagnostic image quality of contrast-enhanced magnetic resonance angiography (CE-MRA) images.

Methods Whole-body CE-MRA data from the lower legs of 27 patients recruited onto a study of asymptomatic atherosclerosis were processed using three deformable image registration algorithms. The resultant diagnostic image quality was evaluated qualitatively in a clinical evaluation by four expert observers, and quantitatively by measuring contrast-to-noise ratios and volumes of blood vessels, and assessing the techniques’ ability to correct for varying degrees of motion.

Results The first registration algorithm (‘AIR’) introduced significant stenosis-mimicking …

Complex Absorbing Potential Method For Dirac Operators. Clusters Of Resonances, Jimmy Kungsman, Michael Melgaard

Articles

For both nonrelativistic and relativistic Hamiltonians, the Complex Absorbing Potential (CAP) method has been applied extensively to calculate resonances in Physics and Chemistry. We study clusters of resonances for the perturbed Dirac operator near the real axis and, in the semiclassical limit, we establish the CAP method rigorously by showing that resonances are perturbed eigenvalues of the nonselfadjoint CAP Hamiltonian, and vice versa.

Getting Started With Research " Writing-Up The Results Of Your Research", Jacinta Browne

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This paper gives an overview of the considerations and practical aspects of writing-up the results of your research which may be of interest to those beginning their research career or simply carrying out a research project for the first time as part of an academic qualification. It outlines practical steps for both writing-up the results of your research as an academic report and thereafter disseminating your results more widely as a peer-reviewed scientific publication.

Getting Started With Research " Beginning: Defining A Research Question And Preparing A Research Plan, Jacinta Browne

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Research is the lifeblood of medicine with innovations being made in the different technologies used to diagnose and / or screen for the presence of disease or to deliver treatments with higher efficacy. Scientific publication is the network of vessels which delivers the lifeblood. The outputs of research provides us with tomorrows medicine. In this series of articles we will be discussing the different aspects of carrying out research from the conception of the research idea to publication in a peer reviewed journal with the cycle repeating again with new research ideas emerging from the research conducted.