Physical Sciences and Mathematics Commons^™

Uhplc In The Analysis Of Drug Components, Rana Chandra Sekhar Reddy Pulagam

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The main objective of this article is to highlight the new trends that have emerged in the enhancement of the HPLC which have given rise to the use of UHPLC. This innovative tool is much more reliable and effective as compared to HPLC, in the investigation of many chemical compounds. In this article, special insight is given on the changes that have been made with regards to both instruments. In this article focus is also placed on the implementation of UPLC in various fields of interest, in order to enhance the processes for which it is utilized. The pros and …

Development Of Method For Detection Of Lead In Samples Collected From Keweenaw Peninsula Mines, Michigan In Collaboration With Environmental Biology Research Students, Sindhu Reddy Aaireddy

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Mining is one of the most important industries and a main cause of global pollution due to release of heavy metals into air, water, and soil. Some of these elements are persistent in the environment for years and bioaccumulation in living organisms causing toxic effects. Such elements are known as PBTs (persistent, bioaccumulate and toxic). The nature of toxicity depends on the properties, size of population exposed to it and period of exposure. For this reason, we are interested in developing a method to detect heavy metals in soil samples, mine tailings, plant and animal samples collected from surroundings of …

Study And Identification Of Environmental Nanoparticles In Governors State University (Gsu's) Agricultural Fields, Ekta Desai

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Main purpose of this project is to study nanoparticles in Governors State University’s agricultural field and design experimental protocol for the same. Nanoparticles have one dimension that measures between 1 - 100 nanometers or less. Nanoparticles are widely used in day to day life such as in medicines, textiles, manufacturing and cosmetics. Due to their wide use, they can enter environment through many ways such as accidental spills during handling. Waste water treatment plant disposal serves as a main source of their entrance into the environment. Analysis of nanoparticles in environmental samples presents a number of challenges, including separation and …

Folic Acid And Its Receptors, Jacqueline Spreadbury

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Folic acid, also known as folate or vitamin B9, is essential for various functions in the human body and life as we know it. Folate is the compound that occurs naturally in food, and folic acid is the synthetic form of this vitamin. Chemically speaking, folic acid has the hydrogen (H+) attached to the compound whereas folate is the conjugate, having lost the hydrogen (H+). Structure, Functions of Folate, Folic Acid in Bacteria, Folate Receptors, and Folic Acid Receptor in Macrophages are discussed in this literature review project. (abstract by OPUS staff)

Synthesis Of A Folate Conjugated Fluorescent Imaging Dye, Daniel Bonner

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In recent years methods of selective targeting of pathologic cells have become increasingly important for both detection and treatment of various cancers. The use of folic acid as a selective therapeutic and targeting agent for cancer cells is becoming ever more significant. This is due to the well characterized up regulation of folate receptors for cancer cells.

In this experiment we focus on the development of a new folate conjugate dye by using a small fluorescent molecule known as Oregon Green 514 for fluorescent imaging of cancer cells. To obtain this objective we I inked folate with Oregon green 514 …