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Physical Sciences and Mathematics Commons™

Open Access. Powered by Scholars. Published by Universities.®

2013

Wayne State University

Wayne State University Theses

Articles 1 - 9 of 9

Full-Text Articles in Physical Sciences and Mathematics

Synthesis And Characterization Of Biodegradable Poly(Vinyl Esters) With Hdac Inhibitory Activity, Kyle Lawrence Horton Jan 2013

Synthesis And Characterization Of Biodegradable Poly(Vinyl Esters) With Hdac Inhibitory Activity, Kyle Lawrence Horton

Wayne State University Theses

HDAC inhibitors are known to have anti-inflammatory properties. HDAC inhibitors are used in combination with Oct4 to generate induced pluripotent stem cells. I hypothesized that polyesters based on simple aliphatic HDAC inhibitors like valproic acid (VPA) and phenylbutyric acid (PBA) can serve as alternatives to existing polyester biomaterials with improved anti-inflammatory properties and as scaffolds for generation of iPSCs when used in combination with layer-by-layer thin films delivering reprogramming transcription factors. Vinyl ester of phenylbutyric acid (VEPA) and vinyl ester of valproic acid (VEVA) were synthesized from their carboxylic acid precursors using an iridium complex catalyst at yields as high …

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Lithogeochemical And Stable Isotope Characteristics Of Bristol And Northern Thorneloe Townships And Its Correlation With Gold Mineralization, Zachary Grant Stevison Jan 2013

Lithogeochemical And Stable Isotope Characteristics Of Bristol And Northern Thorneloe Townships And Its Correlation With Gold Mineralization, Zachary Grant Stevison

Wayne State University Theses

The Porcupine Mining Camp located in the southwestend of the Abitibi Greenstone Belt has been mined extensively for its prolific precious and base metal enrichment. This study targeted Bristol and Northern Thorneloe, fifteen kilometers southwest of Timmins, ON, an area that is of economic interest for its gold mineralization. Rock samples were collected (drill- core and outcrop) throughout both townships and analyzed for their major and trace element composition, These were used to determine hydrothermal alteration signatures as well as specific elemental enrichment that relate to gold mineralization in Bristol-Thorneloe Township. Quartz-carbonate and quartz-carbonate-tourmaline vein samples were also collected near …

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Quantifying The Risks Of Soil Lead In Urban Community Gardens: Sampling To Account For Spatial Variability, Lauren Elizabeth-Korgol Bugdalski Jan 2013

Quantifying The Risks Of Soil Lead In Urban Community Gardens: Sampling To Account For Spatial Variability, Lauren Elizabeth-Korgol Bugdalski

Wayne State University Theses

Urban gardening has recently gained popularity as a way to provide fresh produce and income to urban residents; however, finding suitable sites for urban gardens is challenging because of historical soil lead contamination particularly in post- industrial cities like Detroit, Michigan. Soil lead measurements from three Detroit gardens were modeled using geostatistical techniques to assess risk and alternate sampling strategies. General sampling recommendations for urban gardens were developed based on results of Monte Carlo simulations and associated risk assessment. Variograms and kriged concentration maps indicate spatial variability at scales as small as one meter, with site specific variability in spatial …

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Performance Evaluation Of Voice Chat In Vechicular Ad-Hoc Networks, Vineeth Rakesh Mohan Jan 2013

Performance Evaluation Of Voice Chat In Vechicular Ad-Hoc Networks, Vineeth Rakesh Mohan

Wayne State University Theses

Inter vehicle communication has emerged as an important area of research. With a rapid evolution of social networks, people are constantly looking for social interactions in all types of mobile environment. In this Thesis, we propose a voice chat model for Vehicle-to-Vehicle (V2V) communication that mimics a real-world group talk scenario, and measure its performance using Flood and Scalable broadcast (SBA) protocols. To evaluate the performance of the voice chat, we use different parameters such as group size, network density, transmission range and hop counts to show that our voice chat application is highly feasible in VANET environment. Furthermore, we …

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Analyzing Environmental Change And Prehistoric Hunter Behavior Through A 3d Time-Lapsed Model With Level Auto-Generation And Cultural Algorithms, Samuel Dustin Stanley Jan 2013

Analyzing Environmental Change And Prehistoric Hunter Behavior Through A 3d Time-Lapsed Model With Level Auto-Generation And Cultural Algorithms, Samuel Dustin Stanley

Wayne State University Theses

This paper describes a system containing two portions whose purpose it is to help further the Alpena-Amberley Land Bridge research project and similar archaeological research. The first portion is a "time engine" which one can utilize to navigate through time in order to see how environmental conditions evolved as time passed, or to run experiments during a desired time period. The second portion is a hunting blind cultural algorithm, which is built on top of the time engine as well as Palazzolo's program. In this portion, the AI hunting blinds react to the goals that they are trying to achieve, …

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On The Relationship Between The Vocabulary Of Bug Reports And Source Code, Amunugamage Buddhini Wathsala Bandara Jan 2013

On The Relationship Between The Vocabulary Of Bug Reports And Source Code, Amunugamage Buddhini Wathsala Bandara

Wayne State University Theses

The use of text retrieval techniques on concept location and bug localization yields remarkable benefits. The artifacts found in source code and bug reports contain important information related to the bug localization process. When locating the bugs, it is a programmer's task to formulate effective queries such that most of the predicted terms in the query appear in the relevant defect code, but not in most of the non-relevant source files. These queries are built based on the textual content found in the bug reports, especially the bug title and the description. A large body of research uses bug descriptions …

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Spliceosomal Prp24 Unwinds A Minimal U2/U6 Complex From Yeast, Chandani Manoja Warnasooriya Jan 2013

Spliceosomal Prp24 Unwinds A Minimal U2/U6 Complex From Yeast, Chandani Manoja Warnasooriya

Wayne State University Theses

Splicing plays a major role in eukaryotic gene expression by processing pre-mRNA to form mature mRNA. Pre-mRNAs undergo splicing to remove introns, non–protein coding regions, and religate exons, protein coding regions. This process is catalyzed by the spliceosome, which consists of five small nuclear ribonucleoprotein particles (snRNPs: U1, U2, U4, U5 and U6) and numerous protein factors. Proper assembly of spliceosomal components is critical for function, and thus, defects in assembly can be lethal. Several spliceosomal proteins facilitate structural rearrangements important for spliceosomal assembly and function. Prp24 is an essential factor in U6 snRNP assembly, and it has been proposed …

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Regression Models For Readmission Prediction Using Electronic Medical Records, Yudi Niu Jan 2013

Regression Models For Readmission Prediction Using Electronic Medical Records, Yudi Niu

Wayne State University Theses

Hospital readmissions are not only expensive but are also potentially harmful, and most importantly, they are often preventable. Providing special care for a targeted group of patients who are at a high risk of readmission can significantly improve the chances of avoiding rehospitalization. Despite the significance of this problem, not many researchers have thoroughly investigated it due to the inherent complexities involved in analyzing and estimating the inherent predictive power of such complex hospitalization records. In this thesis, we propose using support vector machines and survival analysis methods to analyze data collected from Electronic Medical Records (EMR). We define the …

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Fabrication Of Two-Dimensional Nanostructures On Glass Using Nanosphere Lithography, Elmer Jim Wang Jan 2013

Fabrication Of Two-Dimensional Nanostructures On Glass Using Nanosphere Lithography, Elmer Jim Wang

Wayne State University Theses

It is desired to have artificial optical materials with controllable optical properties. Optical glass is the most common optical material for various applications. This research will attempt to create a thin layer on the substrate with controllable optical properties. The thin layer is a composite material with nanoscale features and controllable refractive index. Two-dimensional (2D) nanostructures will be created on the surface of optical glass using nanosphere lithography. In comparison with conventional techniques, this approach is more efficient and cost-effective for the creation of large areas of thin surface layers as an artificial material. A uniform monolayer of nanospheres will …

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