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Full-Text Articles in Physical Sciences and Mathematics
Estimating Loop Length From Cryoem Images At Medium Resolutions, Andrew Mcknight, Dong Si, Kamal Al Nasr, Andrey Chernikov, Nikos Chrisochoides, Jing He
Estimating Loop Length From Cryoem Images At Medium Resolutions, Andrew Mcknight, Dong Si, Kamal Al Nasr, Andrey Chernikov, Nikos Chrisochoides, Jing He
Computer Science Faculty Research
Background
De novo protein modeling approaches utilize 3-dimensional (3D) images derived from electron cryomicroscopy (CryoEM) experiments. The skeleton connecting two secondary structures such as α-helices represent the loop in the 3D image. The accuracy of the skeleton and of the detected secondary structures are critical in De novo modeling. It is important to measure the length along the skeleton accurately since the length can be used as a constraint in modeling the protein.
Results
We have developed a novel computational geometric approach to derive a simplified curve in order to estimate the loop length along the skeleton. The method …