Physical Sciences and Mathematics Commons^™

Mathematics Educators And The “Math Wars”: Who Controls The Discourse?, David W. Stinson

Middle-Secondary Education and Instructional Technology Faculty Publications

In this editorial, the author expresses support of a colleague, Professor Jo Boaler of Stanford University, in her actions of going public with the harassment that she has experienced through professional and personal attacks by James Milgram of Stanford University and Wayne Bishop of California State University, Los Angeles.

Observation Of Resistively Detected Hole Spin Resonance And Zero-Field Pseudo-Spin Splitting In Epitaxial Graphene, Ramesh G. Mani, John Hankinson, Claire Berger, Walter A. De Heer

Physics and Astronomy Faculty Publications

Electronic carriers in graphene show a high carrier mobility at room temperature. Thus, this system is widely viewed as a potential future charge-based high-speed electronic material to complement–or replace–silicon. At the same time, the spin properties of graphene have suggested improved capability for spin-based electronics or spintronics and spin-based quantum computing. As a result, the detection, characterization and transport of spin have become topics of interest in graphene. Here we report a microwave photo-excited transport study of monolayer and trilayer graphene that reveals an unexpectedly strong microwave-induced electrical response and dual microwave-induced resonances in the dc resistance. The results suggest …

Simultaneous Determination Of Sitagliptin And Metformin In Pharmaceutical Preparations By Capillary Zone Electrophoresis And Its Application To Human Plasma Analysis, Mohamed Salim, Nahed El-Enany, Fathalah Belal, Mohomad Walash, Gabor Patonay

Chemistry Faculty Publications

A novel, quick, reliable and simple capillary zone electrophoresis CZE method was developed and validated for the simultaneous determination of sitagliptin (SG) and metformin (MF) in pharmaceutical preparations. Separation was carried out in fused silica capillary (50.0 cm total length and 43.0 cm effective length, 49 μm i.d.) by applying a potential of 15 KV (positive polarity) and a running buffer containing 60 mM phosphate buffer at pH 4.0 with UV detection at 203 nm. The samples were injected hydrodynamically for 3 s at 0.5 psi and the temperature of the capillary cartridge was kept at 25 °C. Phenformin was …

On The Brilliance Of Black Children: A Response To A Clarion Call, Erika Bullock, Maisie Gholson, Nathan Alexander

Middle-Secondary Education and Instructional Technology Faculty Publications

In this editorial, three dotoral students in Mathematics Education reflect on their experiences as conference organizers and co-editors of the Proceedings of the 2010 Philadelphia and 2011 Atlanta Bejamin Banneker Associaton Conferences.

Beyond The Numbers: A Benjamin Banneker Association Conference Series, Jacqueline Leonard, Erica R. Davila, David W. Stinson

Middle-Secondary Education and Instructional Technology Faculty Publications

The authors discuss how the "white male math myth" can be effectively debunked by conferences such as the Benjamin Banneker Association Beyond the Numbers conference series, which focus on urban mathematical education and highlight the achievements of black children.

Road Dust Lead (Pb) In Two Neighborhoods Of Urban Atlanta, (Ga, Usa), Daniel Deocampo Ph.D, Phillip Jack Reed, Alexander P. Kalenuik

Geosciences Faculty Publications

Road dust continues to be a major potential reservoir of Pb in the urban environment, and an important potential component of child Pb exposure. This study presents ICP-AES analyses of metals in 72 samples of road dust (<250 μm) collected in the urban core of Atlanta, Georgia. In the Downtown area, median Pb concentrations are ~63 mg/kg Pb, with high values of 278 mg/kg. For comparison, median Pb values in a nearby residential neighborhood (also in the urban core) were ~93 mg/kg, with a high of 972 mg/kg. Geospatial variability is high, with significant variation observed over tens to hundreds of meters. Spearman Rank Correlation tests suggest that Pb and other metals (Cu, Ni, V, Zn) are associated with iron and manganese oxide phases in the residential area, as reported in other cities. However, Pb in the Downtown area is not correlated with the others, suggesting a difference in source or transport history. Given these complexities and the expected differences between road dust and soil Pb, future efforts to assess exposure risk should therefore be based on spatially distributed sampling at very high spatial resolution.

Di-Cationic Arylimidamides Act Against Neospora Caninum Tachyzoites By Interference In Membrane Structure And Nucleolar Integrity And Are Active Against Challenge Infection In Mice, Michelle Schorer, Karim Debache, Fabienne Barna, Thierry Monney, David Boykin, Chad E. Stevens, Andrew Hemphill

Chemistry Faculty Publications

Neospora caninum is considered to be the main cause of bovine abortion in Europe and the USA, leading to considerable financial impact. Losses are caused directly by abortions or indirectly through breeding of calves with impaired viability. Due to the lack of effective chemotherapy against bovine neosporosis, there is a need to develop new anti-protozoal compounds, which would either eliminate the parasite or avoid its transmission. In order to identify compounds of interest, the in vitro activities of 41 di-cationic pentamidine derivatives were studied employing a transgenic N. caninum clone expressing beta-galactosidase as a reporter gene. The arylimidamide DB745, previously …

Insight Into The Modulation Of Shaw2 Kv Channels By General Anesthetics: Structural And Functional Studies Of S4-S5 Linker And S6 C-Terminal Peptides In Micelles By Nmr, Jin Zhang, Xiaoguang Qu, Manuel Covarrubias, Markus W. Germann

Chemistry Faculty Publications

The modulation of the Drosophila Shaw2 Kv channel by 1-alkanols and inhaled anesthetics is correlated with the involvement of the S4–S5 linker and C-terminus of S6, and consistent with stabilization of the channel's closed state. Structural analysis of peptides from S4–S5 (L45) and S6 (S6c), by nuclear magnetic resonance and circular dichroism spectroscopy supports that an α-helical conformation was adopted by L45, while S6c was only in an unstable/dynamic partially folded α-helix in dodecylphosphocholine micelles. Solvent accessibility and paramagnetic probing of L45 revealed that L45 lies parallel to the surface of micelles with charged and polar residues pointing towards the …

A New Essential Protein Discovery Method Based On The Integration Of Protein-Protein Interaction And Gene Expression Data, Min Li, Hanhui Zhang, Jian-Xin Wang, Yi Pan

Computer Science Faculty Publications

The article offers information on a study conducted on the essential protein discovery method, PeC, which is based on the integration of protein-protein interaction and gene expression data. It states that PeC was developed on the basis of the definitions of edge clustering coefficient (ECC) and Pearson's correlation coefficient (PCC). It mentions that a list of essential proteins of Saccharomyces cerevisiae were collected.

Background: Identification of essential proteins is always a challenging task since it requires experimental approaches that are time-consuming and laborious. With the advances in high throughput technologies, a large number of protein-protein interactions are available, which have …

Towards The Identification Of Protein Complexes And Functional Modules By Integrating Ppi Network And Gene Expression Data, Min Li, Xuehong Wu, Jianxin Wang, Yi Pan

Computer Science Faculty Publications

Background: Identification of protein complexes and functional modules from protein-protein interaction (PPI) networks is crucial to understanding the principles of cellular organization and predicting protein functions. In the past few years, many computational methods have been proposed. However, most of them considered the PPI networks as static graphs and overlooked the dynamics inherent within these networks. Moreover, few of them can distinguish between protein complexes and functional modules.

Results: In this paper, a new framework is proposed to distinguish between protein complexes and functional modules by integrating gene expression data into protein-protein interaction (PPI) data. A series of time-sequenced subnetworks …

Iteration Method For Predicting Essential Proteins Based On Orthology And Protein-Protein Interaction Networks, Wei Peng, Jianxin Wang, Weiping Wang, Qing Liu, Fang-Xiang Wu, Yi Pan

Computer Science Faculty Publications

Background: Identification of essential proteins plays a significant role in understanding minimal requirements for the cellular survival and development. Many computational methods have been proposed for predicting essential proteins by using the topological features of protein-protein interaction (PPI) networks. However, most of these methods ignored intrinsic biological meaning of proteins. Moreover, PPI data contains many false positives and false negatives. To overcome these limitations, recently many research groups have started to focus on identification of essential proteins by integrating PPI networks with other biological information. However, none of their methods has widely been acknowledged.

Results: By considering the facts that …

Trip: A Method For Novel Transcript Reconstruction From Paired-End Rna-Seq Reads, Serghei Mangul, Adrian Caciula, Dumitru Brinza, Ion I. Măndoiu, Alexander Zelikovskiy

Computer Science Faculty Publications

Preliminary experimental results on synthetic datasets generated with various sequencing parameters and distribution assumptions show that TRIP has increased transcriptome reconstruction accuracy compared to previous methods that ignore fragment length distribution information.

Guest Editors' Introduction, Jianer Chen, Ion Măndoiu, Raj Sunderraman, Jianxin Wang, Alexander Zelikovskiy

Computer Science Faculty Publications

This Supplement includes a selection of papers presented at the 7th International Symposium on Bioinformatics Research and Application (ISBRA), which was held on May 27-29, 2011 at Central South University in Changsha, China. The technical program of the symposium included 36 extended abstracts presented orally and published in volume 6674 of Springer Verlag’s Lecture Notes in Bioinformatics series. Additionally, the program included 38 short abstracts presented either orally or as posters. Authors of both extended and short abstracts presented at the symposium were invited to submit full versions of their work to this Supplement. Following a rigorous review process, 19 …

Efficient Error Correction For Next-Generation Sequencing Of Viral Amplicons, Pavel Skums, Zoya Dimitrova, David S. Campo, Gilberto Vaughan, Livia Rossi, Joseph C. Forbi, Jonny Yokosawa, Alexander Zelikovskiy, Yury Khudyakov

Computer Science Faculty Publications

Background: Next-generation sequencing allows the analysis of an unprecedented number of viral sequence variants from infected patients, presenting a novel opportunity for understanding virus evolution, drug resistance and immune escape. However, sequencing in bulk is error prone. Thus, the generated data require error identification and correction. Most error-correction methods to date are not optimized for amplicon analysis and assume that the error rate is randomly distributed. Recent quality assessment of amplicon sequences obtained using 454-sequencing showed that the error rate is strongly linked to the presence and size of homopolymers, position in the sequence and length of the amplicon. All …

Voltage Oscillations And Response Dynamics In A Model Of Sensory Hair Cells, Alexander B. Neiman, Kai Dierkes, Benjamin Lindner, Andrey Shilnikov

Neuroscience Institute Faculty Publications

We used a Hodgkin-Huxley type model of the basolateral ionic currents of bullfrog sacculus to study genesis of spontaneous voltage oscillation patterns and how the spontaneous oscillations shape the response of the hair cell to external mechanical stimuli.

Phase-Lag Return Mappings For A 3 Cell Multifunctional Central Pattern Generator, Jeremy Wojcik, Robert Clewley, Andrey Shilnikov

Neuroscience Institute Faculty Publications

We describe and expand on a novel computational approach to reduce detailed models of central pattern generation to equationless return mapping for the phase lags between the constituting bursting interneurons.

Classification And Visualization Of Neural Patterns Using Subspace Analysis Statistical Methods, Jun Xia, Marius Osan, Emilia Titan, Riana Nicolae, Remus Osan

Neuroscience Institute Faculty Publications

The size and complexity of neural data is increasing at a dramatic pace due to rapid advances in experimental technologies. As a result, the data analysis techniques are shifting their focus from single-units to neural populations. The goal is to investigate complex temporal and spatial patterns, as well as to present the results in an intuitive way, allowing for detection and monitoring of relevant neural patterns.

Critical Pedagogy And Teaching Mathematics For Social Justice, David W. Stinson, Carla R. Bidwell, Ginny C. Powell

Middle-Secondary Education and Instructional Technology Faculty Publications

In this article, the authors explore critical pedagogy within the context of mathematics classrooms. The exploration demonstrates the evolving pedagogical practices of mathematics teachers when teaching mathematics is explicitly connected to issues of social justice. To frame the exploration, the authors provide brief overviews of the theoretical tenets of critical pedagogy and of teaching mathematics for social justice. Through using narrative and textual data, the authors illustrate how a graduate-level, critical theory and teaching mathematics for social justice course assisted, in part, in providing not only a new language but also a legitimization in teachers becoming critical mathematics pedagogues.

Transitioning Into Contemporary Theory: Critical Postmodern Theory In Mathematics Education Research, David W. Stinson, Erika Bullock

Middle-Secondary Education and Instructional Technology Faculty Publications

In this theoretical paper, the authors provide an overview of mathematics education as a research domain, identifying and briefly discussing four transitions or historical moments in mathematics education research. Using the Instructional Triangle as a point of reference for the dynamics of mathematics instruction, they illustrate how mathematics education researchers working in different moments explore different questions and use different theoretical perspectives. The authors then provide brief summaries of critical theory and postmodern theory, and suggest critical postmodern theory (CPT) as a hybrid theory that offers new possibilities for conceptualizing and conducting mathematics education research.

2011 Benjamin Banneker Association National Science Foundation Conference Program - Beyond The Numbers: The Brilliance Of Black Children In Mathematics, Benjamin Banneker Association

Middle-Secondary Education and Instructional Technology Faculty Publications

No abstract provided.

Methodology And Application Of Adaptive And Sequential Approaches, Zhengjia Chen, Yichuan Zhao, Ye Cui, Jeanne Kowalski

Mathematics and Statistics Faculty Publications

The clinical trial, a prospective study to evaluate the effect of interventions in humans under prespecified conditions, is a standard and integral part of modern medicine. Many adaptive and sequential approaches have been proposed for use in clinical trials to allow adaptations or modifications to aspects of a trial after its initiation without undermining the validity and integrity of the trial. The application of adaptive and sequential methods in clinical trials has significantly improved the flexibility, efficiency, therapeutic effect, and validity of trials. To further advance the performance of clinical trials and convey the progress of research on adaptive and …

Primitive Zero-Symmetric Sign Pattern Matrices With Zero Diagonal Attaining The Maximum Base, Ling Zhang, Ting-Zhu Huang, Zhongshan Li

Mathematics and Statistics Faculty Publications

The base set of primitive zero-symmetric sign pattern matrices with zero diagonal is {1,2,..., 2n -1}. In this paper, the primitive zero-symmetric sign pattern matrices with zero diagonal attaining the maximal base 2n - 1 are characterized.

The Offenders’ Perspective On Prevention: Guarding Against Victimization And Law Enforcement, Scott Jacques, Danielle Reynald

EBCS Articles

Law-abiding citizens are concerned with deterring and preventing crime. One strategy to accomplish this goal is to increase the costs and reduce the benefits that particular situations present to offenders. This form of crime control is known as situational crime prevention. Like law-abiding persons, offenders must concern themselves with being victimized. Differently, however, offenders must also worry about being detected and punished by formal agents. Thus, situational prevention from the offenders’ perspective is relatively complex, encompassing efforts to block not only opportunities for victimization but also for law enforcement. Building on the work of Clarke, the present study uses qualitative …

Fishing For Animal Rights In The Cove: A Holistic Approach To Animal Advocacy Documentaries, Carrie Packwood Freeman

Communication Faculty Publications

The Oscar-winning 2009 documentary The Cove serves as a thrilling and poignant advocacy tool promoting activism to save free-roaming dolphins off the coast of Japan from kidnapping, enslavement in marine parks, and slaughter for meat. This essay evaluates the ethical and social justice implications of The Cove not just for dolphins but for the animal rights movement as a whole, particularly in terms of how it could challenge the ethicality of humans killing any nonhuman animals for food. Strategic media recommendations are made for how animal protection advocates could better deconstruct the human/animal dualism that is at the root of …