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Full-Text Articles in Physical Sciences and Mathematics

Statistical Criteria For Selecting The Optimal Number Of Untreated Subjects Matched To Each Treated Subject When Using Many-To-One Matching On The Propensity Score, Peter C. Austin Jan 2010

Statistical Criteria For Selecting The Optimal Number Of Untreated Subjects Matched To Each Treated Subject When Using Many-To-One Matching On The Propensity Score, Peter C. Austin

Peter Austin

Propensity-score matching is increasingly being used to estimate the effects of treatments using observational data. In many-to-one (M:1) matching on the propensity score, M untreated subjects are matched to each treated subject using the propensity score. The authors used Monte Carlo simulations to examine the effect of the choice of M on the statistical performance of matched estimators. They considered matching 1–5 untreated subjects to each treated subject using both nearest-neighbor matching and caliper matching in 96 different scenarios. Increasing the number of untreated subjects matched to each treated subject tended to increase the bias in the estimated treatment effect; …


The Performance Of Different Propensity-Score Methods For Estimating Differences In Proportions (Risk Differences Or Absolute Risk Reductions) In Observational Studies, Peter C. Austin Jan 2010

The Performance Of Different Propensity-Score Methods For Estimating Differences In Proportions (Risk Differences Or Absolute Risk Reductions) In Observational Studies, Peter C. Austin

Peter Austin

Propensity score methods are increasingly being used to estimate the effects of treatments on health outcomes using observational data. There are four methods for using the propensity score to estimate treatment effects: covariate adjustment using the propensity score, stratification on the propensity score, propensity-score matching, and inverse probability of treatment weighting (IPTW) using the propensity score. When outcomes are binary, the effect of treatment on the outcome can be described using odds ratios, relative risks, risk differences, or the number needed to treat. Several clinical commentators suggested that risk differences and numbers needed to treat are more meaningful for clinical …