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University of Nebraska - Lincoln
Fumonisin; <i>Fusarium verticillioides</i>; mycotoxin; biosynthesis
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Determining The Biosynthetic Sequence In The Early Steps Of The Fumonisin Pathway By Use Of Three Gene-Disruption Mutants Of Fusarium Verticillioides, Ravi S. Bojja, Ronald Cerny, Robert H. Proctor, Liangcheng Du
Determining The Biosynthetic Sequence In The Early Steps Of The Fumonisin Pathway By Use Of Three Gene-Disruption Mutants Of Fusarium Verticillioides, Ravi S. Bojja, Ronald Cerny, Robert H. Proctor, Liangcheng Du
Ronald Cerny Publications
Fumonisins are polyketide-derived mycotoxins produced by Fusarium verticillioides, a fungal pathogen of corn plants. Although a gene cluster for the biosynthesis of fumonisins has been cloned, the biosynthetic pathway is still not clear. We have used three gene-disrupted mutants, designated ΔFUM1, ΔFUM6, and ΔFUM8, to study the early steps of the pathway. Fumonisins were not produced in single-strain cultures of the ΔFUM1, ΔFUM6, and ΔFUM8 mutants. However, fumonisins were produced by ΔFUM1 or ΔFUM8 mutants when they were cocultured with the ΔFUM6 mutant. No fumonisins were produced when the ΔFUM1 and ΔFUM8 mutants were cocultured. These results suggest that …