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Full-Text Articles in Physical Sciences and Mathematics
Reduced Acetylcholine Receptor Density, Morphological Remodeling, And Butyrylcholinesterase Activity Can Sustain Muscle Function In Acetylcholinesterase Knockout Mice, Michael Adler, Heather A. Manley, Angela L. Purcell, Sharad S. Deshpande, Tracey A. Hamilton, Robert K. Kan, George Oyler, Oksana Lockridge, Ellen G. Duysen, Robert E. Sheridan
Reduced Acetylcholine Receptor Density, Morphological Remodeling, And Butyrylcholinesterase Activity Can Sustain Muscle Function In Acetylcholinesterase Knockout Mice, Michael Adler, Heather A. Manley, Angela L. Purcell, Sharad S. Deshpande, Tracey A. Hamilton, Robert K. Kan, George Oyler, Oksana Lockridge, Ellen G. Duysen, Robert E. Sheridan
US Army Research
The vertebrate neuromuscular junction is designed for rapid transmission of excitatory signals for initiation of muscle contraction.5 Among the features responsible for the high throughput of this synapse are the close proximity of the presynaptic and postsynaptic membranes,10 the direct coupling of acetylcholine (ACh) binding to the opening of the ion channel associated with the nicotinic acetylcholine receptor (nAChR),27 the brief open time of this channel,21,27 and the presence of cholinesterase (ChE) for hydrolysis of ACh.21,30 At the endplate, there are two distinct ChEs for transmitter hydrolysis: acetylcholinesterase (EC 3.1.1.7, AChE) and butyrylcholinesterase (EC 3.1.1.8, BChE).33 Both enzymes can …