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Full-Text Articles in Physical Sciences and Mathematics
Serotonin 5-Ht4 Agonist Activity Of A Series Of Meso-Azanoradamantane Benzamides, Daniel Becker, Roger Nosal, Clara I. Villamil, Gary Gullikson
Serotonin 5-Ht4 Agonist Activity Of A Series Of Meso-Azanoradamantane Benzamides, Daniel Becker, Roger Nosal, Clara I. Villamil, Gary Gullikson
Chemistry: Faculty Publications and Other Works
A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4agonist in the series, with an EC50 of 217 nM.