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Full-Text Articles in Physical Sciences and Mathematics
Synthetic Strategies For The Construction Of Enantiomeric Azanoradamantanes, Daniel Becker, Roger Nosal, Daniel L. Zabrowski, Daniel Flynn
Synthetic Strategies For The Construction Of Enantiomeric Azanoradamantanes, Daniel Becker, Roger Nosal, Daniel L. Zabrowski, Daniel Flynn
Chemistry: Faculty Publications and Other Works
The amino azanoradamantane hexahydro-2,5b-methano-IH-3aS,3aa,6aa-cyclopenta-[clpyrrole-4a-amine 1and the corresponding enantiomer ent-1 have been prepared along with benzamide derivatives SC-52491and SC-52490, respectively, which are of pharmaceutical interest. The key meso-azabicyclo[3.3.0] intermediate 3 was prepared via three separate routes: a [3+2] cycloaddition route, a radical cyclization/ionic cyclization route, and a reductive Pauson-Khand route.