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Effects Of Ammonium Perchlorate On The Thyroid Hormone Levels Of The Sprague-Dawley Rat, James H. King Jr.
Effects Of Ammonium Perchlorate On The Thyroid Hormone Levels Of The Sprague-Dawley Rat, James H. King Jr.
Theses and Dissertations
The purpose of this research was to determine the threshold dose for ammonium perchlorate (AP) in the Sprague-Dawley rat. No dose response data exist for AP and the EPA has studied literature on the subject of perchlorates to determine a provisional reference dose. The Perchiorate Group, a consortium of DoD and industry representatives, believes this provisional reference dose is too conservative. This experiment was executed to provide dose response data on which to base a more accurate reference dose. The study consisted of eight groups of 12 Sprague-Dawley rats, six male and six female, which were exposed to incremental doses …