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Full-Text Articles in Physical Sciences and Mathematics
Effect Of Iron Binding On The Ability Of Crocidolite To Cause Dna Single-Strand Breaks, Jeanne Ann Hardy
Effect Of Iron Binding On The Ability Of Crocidolite To Cause Dna Single-Strand Breaks, Jeanne Ann Hardy
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Fibrous carcinogens, such as crocidolite asbestos, are known to catalyze many of the same reactions as iron, namely O2 consumption, generation of reduced oxygen species, and damage to DNA, such as strand breaks, and modifications of bases. Upon inhalation, fibers are also known to become coated with an iron-rich material. The mechanism by which this iron is bound to fibers in the lung is not known, and the effect of this additional iron on the reactivity of the fibers is also not well understood. The studies described here were undertaken to elucidate the abilities of crocidolite asbestos, in its …
The Pharmacodynamics And Toxicodynamics Of Inotropic Drugs In Calves With Natural And Artificial Hearts, Scott D. Everett
The Pharmacodynamics And Toxicodynamics Of Inotropic Drugs In Calves With Natural And Artificial Hearts, Scott D. Everett
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Inotropic support for the failing myocardium as the therapy for congestive heart failure (CHF) is intended to achieve an increase in cardiac output via positive responses in myocardial contractility and vasodilation. A novel approach to differentiate these two responses is the use of an animal with an implanted total artificial heart (TAH). Three inotropic drugs, dobutamine, enoximone, and pimobendan, were tested in eight animals with their natural heart intact and five animals implanted with a TAH. Baseline values of the TAH and natural heart (NH) were compared to determine their hemodynamic similarities. Each of the three drugs was given randomly …