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Full-Text Articles in Physical Sciences and Mathematics

Cad Tools For Dna Micro-Array Design, Manufacture And Application, Nisar Hundewale Dec 2006

Cad Tools For Dna Micro-Array Design, Manufacture And Application, Nisar Hundewale

Computer Science Dissertations

Motivation: As the human genome project progresses and some microbial and eukaryotic genomes are recognized, numerous biotechnological processes have attracted increasing number of biologists, bioengineers and computer scientists recently. Biotechnological processes profoundly involve production and analysis of highthroughput experimental data. Numerous sequence libraries of DNA and protein structures of a large number of micro-organisms and a variety of other databases related to biology and chemistry are available. For example, microarray technology, a novel biotechnology, promises to monitor the whole genome at once, so that researchers can study the whole genome on the global level and have a better picture of …


No Free Lunch, Bayesian Inference, And Utility: A Decision-Theoretic Approach To Optimization, Christopher Kenneth Monson Apr 2006

No Free Lunch, Bayesian Inference, And Utility: A Decision-Theoretic Approach To Optimization, Christopher Kenneth Monson

Theses and Dissertations

Existing approaches to continuous optimization are essentially mechanisms for deciding which locations should be sampled in order to obtain information about a target function's global optimum. These methods, while often effective in particular domains, generally base their decisions on heuristics developed in consideration of ill-defined desiderata rather than on explicitly defined goals or models of the available information that may be used to achieve them. The problem of numerical optimization is essentially one of deciding what information to gather, then using that information to infer the location of the global optimum. That being the case, it makes sense to model …


Doppler-Only Multistatic Radar, Dustin G. Mixon Mar 2006

Doppler-Only Multistatic Radar, Dustin G. Mixon

Theses and Dissertations

In order to estimate the position and velocity of a target, most multistatic radar systems require multiple independent target measurements, such as angle-of-arrival, time-of-arrival, and Doppler information. Though inexpensive and reliable, Doppler-only systems have not been widely implemented due to the inherent nonlinear problem of determining a target’s position and velocity from their measurements. We solve this problem. In particular, we first establish the lack of observability in the Doppler-only bistatic system, thereby demonstrating the need for multiple transmitters and/or receivers. Next, for a multistatic system with a sufficient number of transmitter-receiver pairs, we invoke classical optimization techniques, such as …