Physical Sciences and Mathematics Commons^™

Network Analytics For The Mirna Regulome And Mirna-Disease Interactions, Joseph Jayakar Nalluri

Theses and Dissertations

miRNAs are non-coding RNAs of approx. 22 nucleotides in length that inhibit gene expression at the post-transcriptional level. By virtue of this gene regulation mechanism, miRNAs play a critical role in several biological processes and patho-physiological conditions, including cancers. miRNA behavior is a result of a multi-level complex interaction network involving miRNA-mRNA, TF-miRNA-gene, and miRNA-chemical interactions; hence the precise patterns through which a miRNA regulates a certain disease(s) are still elusive. Herein, I have developed an integrative genomics methods/pipeline to (i) build a miRNA regulomics and data analytics repository, (ii) create/model these interactions into networks and use optimization techniques, motif …

Bi- And Multi Level Game Theoretic Approaches In Mechanical Design, Ehsan Ghotbi

Theses and Dissertations

This dissertation presents a game theoretic approach to solve bi and multi-level optimization problems arising in mechanical design. Toward this end, Stackelberg (leader-follower), Nash, as well as cooperative game formulations are considered. To solve these problems numerically, a sensitivity based approach is developed in this dissertation. Although game theoretic methods have been used by several authors for solving multi-objective problems, numerical methods and the applications of extensive games to engineering design problems are very limited. This dissertation tries to fill this gap by developing the possible scenarios for multi-objective problems and develops new numerical approaches for solving them.

This dissertation …