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Full-Text Articles in Physical Sciences and Mathematics

Machine Learning Models For Deciphering Regulatory Mechanisms And Morphological Variations In Cancer, Saman Farahmand May 2021

Machine Learning Models For Deciphering Regulatory Mechanisms And Morphological Variations In Cancer, Saman Farahmand

Graduate Doctoral Dissertations

The exponential growth of multi-omics biological datasets is resulting in an emerging paradigm shift in fundamental biological research. In recent years, imaging and transcriptomics datasets are increasingly incorporated into biological studies, pushing biology further into the domain of data-intensive-sciences. New approaches and tools from statistics, computer science, and data engineering are profoundly influencing biological research. Harnessing this ever-growing deluge of multi-omics biological data requires the development of novel and creative computational approaches. In parallel, fundamental research in data sciences and Artificial Intelligence (AI) has advanced tremendously, allowing the scientific community to generate a massive amount of knowledge from data. Advances …


Evolutionary Game Theoretic Multi-Objective Optimization Algorithms And Their Applications, Yi Ren Cheng May 2017

Evolutionary Game Theoretic Multi-Objective Optimization Algorithms And Their Applications, Yi Ren Cheng

Graduate Doctoral Dissertations

Multi-objective optimization problems require more than one objective functions to be optimized simultaneously. They are widely applied in many science fields, including engineering, economics and logistics where optimal decisions need to be taken in the presence of trade-offs between two or more conicting objectives. Most of the real world multi-objective optimization problems are NP-Hard problems. It may be too computationally costly to find an exact solution but sometimes a near optimal solution is sufficient. In these cases, Multi-Objective Evolutionary Algorithms (MOEAs) provide good approximate solutions to problems that cannot be solved easily using other techniques. However Evolutionary Algorithm is not …