Physical Sciences and Mathematics Commons^™

Mathematically Modeling Pcr: An Asymptotic Approximation With Potential For Optimization, Martha J. Garlick

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

A mathematical model for PCR (Polymerase Chain Reaction) is developed using the law of mass action. Differential equations are written from the chemical equations, preserving the detail of the complementary DNA single strand being extended one bas e pair at a time. The equations for the annealing stage are solved analytically. The method of multiple scales is used to approximate solutions for the extension stage. A map is then developed from the solutions to simulate PCR. The advantage of this model is the ability to use the map to optimize the process. Our results suggest that dynamically optimizing the extension …

Test Suite For Multiobjective Optimization And Results Using Normal Boundary Intersection (Nbi) In Design Explorer, Siva Kumar Natarajan

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Several methods have been developed to solve multiobjective optimization problems (MOP's). One of these, Normal Boundary Intersection (NBI), is a method developed by John Dennis and Indraneel Das. NBI is used at The Boeing Company as a tool to solve MOP's. This report presents a test suite of MOP's that I developed for Boeing during me internship in summer 2003.

The problems in the test suite were chosen to represent the different types of multiobjective optimization problems that could arise in practice and the complexities involved in solving them. These problems range from those that have nice convex Pareto surfaces …

Computer Simulation And Homogenization In Heating Design Optimization, Daniel K. Balls

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The ability to ensure uniformity of temperature within a given finite physical region is an essential element in the success of many scientific processes, especially those that involve extreme fluctuation in temperature. Such a process is performed in an instrument called the LightTyper developed by Idaho Technology, Inc. of Salt Lake City Utah. This paper details the development and results of a scheme intended to obtain a heating design that ensures a high degree of temperature uniformity within the Idaho Technology instrument. Due to the experiments performed during this project, we were able to answer many questions that concerned finding …