Physical Sciences and Mathematics Commons^™

A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb

Masters Theses

One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …

Loss Scaling And Step Size In Deep Learning Optimizatio, Nora Alosily

Dissertations

Deep learning training consumes ever-increasing time and resources, and that is
due to the complexity of the model, the number of updates taken to reach good
results, and both the amount and dimensionality of the data. In this dissertation,
we will focus on making the process of training more efficient by focusing on the
step size to reduce the number of computations for parameters in each update.
We achieved our objective in two new ways: we use loss scaling as a proxy for
the learning rate, and we use learnable layer-wise optimizers. Although our work
is perhaps not the first …

Peer-To-Peer Energy Trading In Smart Residential Environment With User Behavioral Modeling, Ashutosh Timilsina

Theses and Dissertations--Computer Science

Electric power systems are transforming from a centralized unidirectional market to a decentralized open market. With this shift, the end-users have the possibility to actively participate in local energy exchanges, with or without the involvement of the main grid. Rapidly reducing prices for Renewable Energy Technologies (RETs), supported by their ease of installation and operation, with the facilitation of Electric Vehicles (EV) and Smart Grid (SG) technologies to make bidirectional flow of energy possible, has contributed to this changing landscape in the distribution side of the traditional power grid.

Trading energy among users in a decentralized fashion has been referred …

Finding Optimal Cayley Map Embeddings Using Genetic Algorithms, Jacob Buckelew

Honors Program Theses

Genetic algorithms are a commonly used metaheuristic search method aimed at solving complex optimization problems in a variety of fields. These types of algorithms lend themselves to problems that can incorporate stochastic elements, which allows for a wider search across a search space. However, the nature of the genetic algorithm can often cause challenges regarding time-consumption. Although the genetic algorithm may be widely applicable to various domains, it is not guaranteed that the algorithm will outperform other traditional search methods in solving problems specific to particular domains. In this paper, we test the feasibility of genetic algorithms in solving a …

Optimal Communication Structures For Concurrent Computing, Andrii Berdnikov

Doctoral Dissertations

This research focuses on communicative solvers that run concurrently and exchange information to improve performance. This “team of solvers” enables individual algorithms to communicate information regarding their progress and intermediate solutions, and allows them to synchronize memory structures with more “successful” counterparts. The result is that fewer nodes spend computational resources on “struggling” processes. The research is focused on optimization of communication structures that maximize algorithmic efficiency using the theoretical framework of Markov chains. Existing research addressing communication between the cooperative solvers on parallel systems lacks generality: Most studies consider a limited number of communication topologies and strategies, while the …

Deep Learning And Optimization In Visual Target Tracking, Mohammadreza Javanmardi

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Visual tracking is the process of estimating states of a moving object in a dynamic frame sequence. It has been considered as one of the most paramount and challenging topics in computer vision. Although numerous tracking methods have been introduced, developing a robust algorithm that can handle different challenges still remains unsolved. In this dissertation, we introduce four different trackers and evaluate their performance in terms of tracking accuracy on challenging frame sequences. Each of these trackers aims to address the drawbacks of their peers. The first developed method is called a structured multi-task multi-view tracking (SMTMVT) method, which exploits …

Benchmarks And Controls For Optimization With Quantum Annealing, Erica Kelley Grant

Doctoral Dissertations

Quantum annealing (QA) is a metaheuristic specialized for solving optimization problems which uses principles of adiabatic quantum computing, namely the adiabatic theorem. Some devices implement QA using quantum mechanical phenomena. These QA devices do not perfectly adhere to the adiabatic theorem because they are subject to thermal and magnetic noise. Thus, QA devices return statistical solutions with some probability of success where this probability is affected by the level of noise of the system. As these devices improve, it is believed that they will become less noisy and more accurate. However, some tuning strategies may further improve that probability of …

Micro Grid Control Optimization With Load And Solar Prediction, Shaju Saha

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Using renewable energy can save money and keep the environment cleaner. Installing a solar PV system is a one-time cost but it can generate energy for a lifetime. Solar PV does not generate carbon emissions while producing power. This thesis evaluates the value of being able to make accurate predictions in the use of solar energy. It uses predicted solar power and load for a system and a battery to store the energy for future use and calculates the operating cost or profit in several designed conditions. Various factors like a different place, tuning the capacity of sources, changing buy/sell …

High Multiplicity Strip Packing Problem With Three Rectangle Types, Andy Yu

Electronic Thesis and Dissertation Repository

The two-dimensional strip packing problem (2D-SPP) involves packing a set R = {r₁, ..., r_n} of n rectangular items into a strip of width 1 and unbounded height, where each rectangular item r_i has width 0 < w_i ≤ 1 and height 0 < h_i ≤ 1. The objective is to find a packing for all these items, without overlaps or rotations, that minimizes the total height of the strip used. 2D-SPP is strongly NP-hard and has practical applications including stock cutting, scheduling, and reducing peak power demand in smart-grids.

This thesis considers …

Gem-Pso: Particle Swarm Optimization Guided By Enhanced Memory, Kevin Fakai Chen

Honors Projects

Particle Swarm Optimization (PSO) is a widely-used nature-inspired optimization technique in which a swarm of virtual particles work together with limited communication to find a global minimum or optimum. PSO has has been successfully applied to a wide variety of practical problems, such as optimization in engineering fields, hybridization with other nature-inspired algorithms, or even general optimization problems. However, PSO suffers from a phenomenon known as premature convergence, in which the algorithm's particles all converge on a local optimum instead of the global optimum, and cannot improve their solution any further. We seek to improve upon the standard Particle Swarm …

Two-On-One Pursuit With A Non-Zero Capture Radius, Patrick J. Wasz

Theses and Dissertations

In this paper, we revisit the "Two Cutters and Fugitive Ship" differential game that was addressed by Isaacs, but move away from point capture. We consider a two-on-one pursuit-evasion differential game with simple motion and pursuers endowed with circular capture sets of radius l > 0. The regions in the state space where only one pursuer effects the capture and the region in the state space where both pursuers cooperatively and isochronously capture the evader are characterized, thus solving the Game of Kind. Concerning the Game of Degree, the algorithm for the synthesis of the optimal state feedback strategies of the …

Gradient Estimation For Attractor Networks, Thomas Flynn

Dissertations, Theses, and Capstone Projects

It has been hypothesized that neural network models with cyclic connectivity may be more powerful than their feed-forward counterparts. This thesis investigates this hypothesis in several ways. We study the gradient estimation and optimization procedures for several variants of these networks. We show how the convergence of the gradient estimation procedures are related to the properties of the networks. Then we consider how to tune the relative rates of gradient estimation and parameter adaptation to ensure successful optimization in these models. We also derive new gradient estimators for stochastic models. First, we port the forward sensitivity analysis method to the …

Investigating Genetic Algorithm Optimization Techniques In Video Games, Nathan Ambuehl

Undergraduate Honors Theses

Immersion is essential for player experience in video games. Artificial Intelligence serves as an agent that can generate human-like responses and intelligence to reinforce a player’s immersion into their environment. The most common strategy involved in video game AI is using decision trees to guide chosen actions. However, decision trees result in repetitive and robotic actions that reflect an unrealistic interaction. This experiment applies a genetic algorithm that explores selection, crossover, and mutation functions for genetic algorithm implementation in an isolated Super Mario Bros. pathfinding environment. An optimized pathfinding AI can be created by combining an elitist selection strategy with …

Network Analytics For The Mirna Regulome And Mirna-Disease Interactions, Joseph Jayakar Nalluri

Theses and Dissertations

miRNAs are non-coding RNAs of approx. 22 nucleotides in length that inhibit gene expression at the post-transcriptional level. By virtue of this gene regulation mechanism, miRNAs play a critical role in several biological processes and patho-physiological conditions, including cancers. miRNA behavior is a result of a multi-level complex interaction network involving miRNA-mRNA, TF-miRNA-gene, and miRNA-chemical interactions; hence the precise patterns through which a miRNA regulates a certain disease(s) are still elusive. Herein, I have developed an integrative genomics methods/pipeline to (i) build a miRNA regulomics and data analytics repository, (ii) create/model these interactions into networks and use optimization techniques, motif …

Indefinite Knapsack Separable Quadratic Programming: Methods And Applications, Jaehwan Jeong

Doctoral Dissertations

Quadratic programming (QP) has received significant consideration due to an extensive list of applications. Although polynomial time algorithms for the convex case have been developed, the solution of large scale QPs is challenging due to the computer memory and speed limitations. Moreover, if the QP is nonconvex or includes integer variables, the problem is NP-hard. Therefore, no known algorithm can solve such QPs efficiently. Alternatively, row-aggregation and diagonalization techniques have been developed to solve QP by a sub-problem, knapsack separable QP (KSQP), which has a separable objective function and is constrained by a single knapsack linear constraint and box constraints. …

High Multiplicity Strip Packing, Devin Price

Electronic Thesis and Dissertation Repository

An instance of the two-dimensional strip packing problem is specified by n rectangular items, each having a width, 0 < w_n ≤ 1, and height, 0 < h_n ≤ 1. The objective is to place these items into a strip of width 1, without rotations, such that they are nonoverlapping and the total height of the resulting packing is minimized. In this thesis, we consider the version of the two-dimensional strip packing problem where there is a constant number K of distinct rectangle sizes and present an OPT + K - 1 polynomial-time approximation algorithm for it. This beats a previous algorithm …

Artificial Immune Systems And Particle Swarm Optimization For Solutions To The General Adversarial Agents Problem, Jeremy Mange

Dissertations

The general adversarial agents problem is an abstract problem description touching on the fields of Artificial Intelligence, machine learning, decision theory, and game theory. The goal of the problem is, given one or more mobile agents, each identified as either “friendly" or “enemy", along with a specified environment state, to choose an action or series of actions from all possible valid choices for the next “timestep" or series thereof, in order to lead toward a specified outcome or set of outcomes. This dissertation explores approaches to this problem utilizing Artificial Immune Systems, Particle Swarm Optimization, and hybrid approaches, along with …