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Full-Text Articles in Physical Sciences and Mathematics
A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb
A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb
Masters Theses
One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …
Optimal Communication Structures For Concurrent Computing, Andrii Berdnikov
Optimal Communication Structures For Concurrent Computing, Andrii Berdnikov
Doctoral Dissertations
This research focuses on communicative solvers that run concurrently and exchange information to improve performance. This “team of solvers” enables individual algorithms to communicate information regarding their progress and intermediate solutions, and allows them to synchronize memory structures with more “successful” counterparts. The result is that fewer nodes spend computational resources on “struggling” processes. The research is focused on optimization of communication structures that maximize algorithmic efficiency using the theoretical framework of Markov chains. Existing research addressing communication between the cooperative solvers on parallel systems lacks generality: Most studies consider a limited number of communication topologies and strategies, while the …
Developing An Optimal Model For Infant Home Visitation, Isaac Atuahene
Developing An Optimal Model For Infant Home Visitation, Isaac Atuahene
Doctoral Dissertations
The United States, Great Britain, Denmark, Canada and many other countries have accepted home visitation (HV) as a promising strategy for interventions for infants after births and for their mothers. Prior HV studies have focused on theoretical foundations, evaluations of programs, cost/benefit analysis and cost estimation by using hospital/payer/insurance data to prove its effectiveness and high cost. As governments and private organizations continue to fund HVs, it is an opportune time to develop and formulate operations research (OR) models of HV coverage, quality and cost so they might be used in program implementation as done for adult home healthcare (HHC) …