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Full-Text Articles in Physical Sciences and Mathematics
Development Of Bifunctional Peptides As Scaffolds For Bifunctional Catalysis And A Novel Method Of Peptide Stapling Using Squaric Esters, Adam X. Wayment
Development Of Bifunctional Peptides As Scaffolds For Bifunctional Catalysis And A Novel Method Of Peptide Stapling Using Squaric Esters, Adam X. Wayment
Theses and Dissertations
Enzymes are some of nature's most powerful tools in chemical processes. However, their molecular complexity makes them difficult to synthesize and complicates their application in traditional organic synthesis. Peptides, a building block of enzymes, can be rapidly synthesized and have been used as a possible alternative in achieving enzyme-like catalysis. However, most peptide-based catalysts are limited in reaction-scope and are unable to incorporate traditional organic catalysts. We have designed a helical peptide scaffold capable of being functionalized with a wide variety of organocatalysts as well as transition-metal based catalysts. In order to understand how the peptide structure effects reactivity and …
Photoinduced Alpha-Hydroxy C–H Alkylation Of Mono-Alcohols Via Hydrogen Atom Transfer (Hat) Of An Activated Boron-Containing Complex, Courtney Deanna Glenn
Photoinduced Alpha-Hydroxy C–H Alkylation Of Mono-Alcohols Via Hydrogen Atom Transfer (Hat) Of An Activated Boron-Containing Complex, Courtney Deanna Glenn
Graduate Theses, Dissertations, and Problem Reports
Hydroxy (-OH) groups are one of the most abundant functional groups found in natural products and pharmaceuticals with many of these compounds containing multiple alcohol classes. The ability to selectively functionalize a specific α-OH C–H bond in the presence of other competitive sites would provide straightforward access to new, potentially bioactive compounds. In recent literature, photoredox catalysis has been implemented to perform site and stereoselective α-OH C–H functionalization of cis-diol containing substrates. Incorporating an organoboron cocatalyst into these systems have proven to be crucial in decreasing the bond dissociation energy (BDE) and increasing hydricity of the α-OH C–H bond …
Activation Of Hydrogen By Sterically Modulated Coinage Metal Catalysts Via Mutual Quenching Of Hard/Soft Acid/Base Mismatches, Zach Leibowitz
Activation Of Hydrogen By Sterically Modulated Coinage Metal Catalysts Via Mutual Quenching Of Hard/Soft Acid/Base Mismatches, Zach Leibowitz
Honors Projects
To mitigate the devastating environmental impacts of climate change in the coming decades, it is imperative that we replace the use of fossil fuels with renewable energy sources such as wind, solar, and hydroelectric. As these renewable energy sources are inherently intermittent, there exists a need for sustainable mechanisms to store renewable energy for later use. While the direct use of dihydrogen (H2) as a combustible fuel would allow for energy storage without the harmful release of carbon dioxide (CO2) upon combustion, the practicality of H2 as a synthetic fuel is limited by its low …