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Full-Text Articles in Physical Sciences and Mathematics
Computational Study Of Lawesson’S Reagent Mediated Fluorenone Dimerization Forming 9,9’-Bifluorenylidene, Andrew Jourdan Eckelmann
Computational Study Of Lawesson’S Reagent Mediated Fluorenone Dimerization Forming 9,9’-Bifluorenylidene, Andrew Jourdan Eckelmann
MSU Graduate Theses
The ambition of this work is to start a path to the a priori rational design of high yield production for electron acceptors with finely tuned band gaps, from the comfort of an armchair. To this end, organic photovoltaics offer a cheap and sustainable means of manufacture using readily available materials and avoids the toxicity of some of the heavy metals used in first and second-generation solar cells such as cadmium. The microwave assisted Lawesson’s reagent mediated one-pot one-step solventless synthesis takes less than 3 minutes and results in an 84% yield of 9,9’-bifluorenylidene from two equivalents of fluorenone. While …
Synthesis Of Oxadiazoles And Examination Of Steric Effects In A Cyclodehydration Reaction, Norah Young
Synthesis Of Oxadiazoles And Examination Of Steric Effects In A Cyclodehydration Reaction, Norah Young
Undergraduate Honors Thesis Projects
The objective of this project is to develop a general substrate scope by testing various steric and electronic effects. This is pursued by developing triphenylphosphine dibromide (PPh3Br2) as an effective cyclodehydration reagent for use with a variety of hydrazides and sterically and electronically different benzoic acids. The two phases of the experiment include assessing yield through a cyclodehydration reaction and comparing that yield to the steric hindrance and molecular structure recorded in different databases. The cyclodehydration reaction uses ortho-substituted benzoic acid with store bought PPh3Br2, and compares those yields to the use of a two step-one pot reaction in place …
Synthesis Of 1,4-Triazolyl Combretacoumarins As Potential Anticancer Agents, Tashrique A. Khandaker
Synthesis Of 1,4-Triazolyl Combretacoumarins As Potential Anticancer Agents, Tashrique A. Khandaker
Dissertations and Theses
Coumarins are natural compounds that have various physiological and therapeutic properties, making them pharmacologically important. Combretastatin A-4 (CA-4) is a microtubule-binding agent that has potent cytotoxic effects against human cell lines. In CA-4 the trimethoxyarene moiety plays a crucial role in its carcinopreventive effect. Thus, we decided to synthesize novel, potential anti-cancer agents called 1,4-triazolyl combretacoumarins, by coupling different coumarins and the functionally relevant group of CA-4 i.e, the trimethoxyarene moiety, via a 1,2,3-triazolyl ring using a copper-catalyzed [3 + 2] azide-alkyne cycloaddition (CuAAC) reaction, which is a very atom-economical reaction. The coupling partners, 4-azidocoumarins, required for making these …