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Preparation, Chemistry, And Characterization Of Hypervalent Organosulfur Fluorides, Paul R. Savoie
Preparation, Chemistry, And Characterization Of Hypervalent Organosulfur Fluorides, Paul R. Savoie
Legacy Theses & Dissertations (2009 - 2024)
Since the discovery of the pentafluorosulfanyl (SF5) group around the 1960s, progress in exploring the chemistry of aliphatic SF5-containing compounds stagnated because of a lack of efficient synthetic methods. More recent developments in the preparations of SF5-containing compounds afforded easier access to these compounds, and sparked great interest in exploring their chemistry. Chapter 1 discusses the development of efficient methods used to prepare SF5-containing aliphatic compounds.
Fluorinated Hypervalent Sulfur Compounds In Synthesis, Cortney Von Hahmann
Fluorinated Hypervalent Sulfur Compounds In Synthesis, Cortney Von Hahmann
Legacy Theses & Dissertations (2009 - 2024)
The polar and steric effects of pentafluorosulfanyl (SF5) substitution on selectivity and reactivity were investigated in the ketene imine [2+2] cycloaddition reaction. The kinetic resolution of racemic aldimines rely on the stereocontrol of cyclization by dipolar substituent effects. Functionalized SF5-bearing β-lactams are used in the preparation of conformationally constrained SF5-containing β-amino acids and peptides, in the study of novel antibacterial agents and in the design of new β-lactamase inhibitors.