Physical Sciences and Mathematics Commons^™

Using Sequence Analysis To Perform Application-Based Anomaly Detection Within An Artificial Immune System Framework, Larissa A. O'Brien

Theses and Dissertations

The Air Force and other Department of Defense (DoD) computer systems typically rely on traditional signature-based network IDSs to detect various types of attempted or successful attacks. Signature-based methods are limited to detecting known attacks or similar variants; anomaly-based systems, by contrast, alert on behaviors previously unseen. The development of an effective anomaly-detecting, application based IDS would increase the Air Force's ability to ward off attacks that are not detected by signature-based network IDSs, thus strengthening the layered defenses necessary to acquire and maintain safe, secure communication capability. This system follows the Artificial Immune System (AIS) framework, which relies on …

Analysis Of Gene Expression Data Using Expressionist 3.1 And Genespring 4.2, Indu Shrivastava

Theses

The purpose of this study was to determine the differences in the gene expression analysis methods of two data mining tools, Expressionistic^TM 3.1 and GeneSpring^TM 4.2 with focus on basic statistical analysis and clustering algorithms. The data for this analysis was derived from the hybridization of Rattus norvegicus RNA to the Affymetrix RG34A GeneChip. This analysis was derived from experiments designed to identify changes in gene expression patterns that were induced in vivo by an experimental treatment.

The tools were found to be comparable with respect to the list of statistically significant genes that were up-regulated by more …