Physical Sciences and Mathematics Commons^™

A Method For Finding Standard Error Estimates For Rma Expression Levels Using Bootstrap, Gabriel Nicholas

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Oligonucleotide arrays are used in many applications. Affymetrix GeneChip arrays are widely used. Before researchers can use the information from these arrays, the raw data must be transformed and summarized into a more meaningful and usable form. One of the more popular methods for doing so is RMA (Robust Multi-array Analysis).

A problem with RMA is that the end result (estimated gene expression levels) is based on a fairly complicated process that is unusual. Specifically, there is no closed-form estimate of standard errors for the estimated gene expression levels. The current recommendation is to use a naive estimate for the …

Comparison Of Bootstrap And Jacknife Statistical Procedures, Amanuel Gobena

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

This report compares the bootstrapping to jacknifing statistical procedures in terms in bias, confidence interval and estimation of median. Related literature have been reviewed. A bootstrap allows a researcher to get an approximation to the distribution of possibly complicated statistical summaries. It is based on random sampling with replacement from experimental units. Jacknife has also been in operation prior to bootstrapping statistical procedure. The jacknife divides the data into subgroups and obtains partial estimates of these subgroups by omitting one subgroup at a time. When both of these statistical resampling procedures are compared the bootstrap has less bias, more accurate …