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Full-Text Articles in Physical Sciences and Mathematics
Thioenamide Synthesis Inspired By Peptide Macrocycles, Joshua Allen Lutz
Thioenamide Synthesis Inspired By Peptide Macrocycles, Joshua Allen Lutz
LSU Doctoral Dissertations
Despite advances in medicine, antibiotic resistance threatens to return once preventable diseases to the human population. The microbisporicins are 24-amino acid antibiotic peptides belonging to the lantibiotic class, which pathogens have been slow to develop resistance. The uncommon post-translational modification S-[(Z)-2-aminovinyl]-D-cysteine (AviCys) is likely crucial to their activity, and appears in a small number of other peptides with compelling biological activities. Total synthesis of an AviCys-containing peptide has eluded the chemical community.
The primary challenge of AviCys synthesis is the construction of a thioenamide functional group. We demonstrate that acid-promoted reactions between an amide and …
I. Synthesis Of Ascarosides For Biological Evaluation And Ii. Development Of Visible Light-Promoted Selenofunctionalization And Grafting Of Aryl Iodides, Elizabeth Susan Conner Balapitiya
I. Synthesis Of Ascarosides For Biological Evaluation And Ii. Development Of Visible Light-Promoted Selenofunctionalization And Grafting Of Aryl Iodides, Elizabeth Susan Conner Balapitiya
LSU Doctoral Dissertations
This dissertation focuses on analog synthesis for biological evaluation and visible light promoted method development. Chapter 1 centers upon the synthesis of Caenorhabditis elegans dauer pheromone analogs. C. elegans is a nematode which, in times of environmental stress, enters a dauer stage. Two highly conserved pathways, which play important roles in some diseases in higher organisms, monitor dauer formation: TGF-β and IGF-1. Dauer formation is triggered by the nematode’s chemosensation of the dauer pheromone, consisting of a group of previously-isolated ascarosides. These compounds differ in chain length, saturation, terminal functionality of side chain, ω vs. ω-1 oxygenation and presence of …
A Study Of Some Nitroso Compounds., Cilton Watson Tate
A Study Of Some Nitroso Compounds., Cilton Watson Tate
LSU Historical Dissertations and Theses
No abstract provided.
Acetic-Oxalic Anhydride. Part I. A Study Of Some N-Alkyl-Cyclohexylcarbinols. Part Ii., Walter Maurey Henley
Acetic-Oxalic Anhydride. Part I. A Study Of Some N-Alkyl-Cyclohexylcarbinols. Part Ii., Walter Maurey Henley
LSU Historical Dissertations and Theses
No abstract provided.
The Reaction Of Diphenylketenephenylimine And Phenyl-Lithium. Part I. The Bromo-2-Nitro-Benzoic Acids. Part Ii., Tillman Rupert Pullig
The Reaction Of Diphenylketenephenylimine And Phenyl-Lithium. Part I. The Bromo-2-Nitro-Benzoic Acids. Part Ii., Tillman Rupert Pullig
LSU Historical Dissertations and Theses
No abstract provided.
The Theory Of Fractional Solvent Extraction And Its Application To Creosol Separation., Ada Lorine Ryland
The Theory Of Fractional Solvent Extraction And Its Application To Creosol Separation., Ada Lorine Ryland
LSU Historical Dissertations and Theses
No abstract provided.
The Reaction Of Organomagnesium Compounds With Triketones., Reuben F. Miller
The Reaction Of Organomagnesium Compounds With Triketones., Reuben F. Miller
LSU Historical Dissertations and Theses
No abstract provided.
A Kinetic Study Of The Autocatalytic Reaction Between Aniline And Benzoic-Anhydride In A Non-Polar Solvent., Jack Warren Knight
A Kinetic Study Of The Autocatalytic Reaction Between Aniline And Benzoic-Anhydride In A Non-Polar Solvent., Jack Warren Knight
LSU Historical Dissertations and Theses
No abstract provided.
Selected Studies Of Organic Reagents., Louis Johnson Conrad
Selected Studies Of Organic Reagents., Louis Johnson Conrad
LSU Historical Dissertations and Theses
No abstract provided.
The Cleavage Of Acylacetonitriles By Phenylmagnesium-Bromide., Murrell Pinckney Morris
The Cleavage Of Acylacetonitriles By Phenylmagnesium-Bromide., Murrell Pinckney Morris
LSU Historical Dissertations and Theses
No abstract provided.
A Study Of The Vogel Reaction For The Determination Of Cobalt., Charles Gosse De Vries
A Study Of The Vogel Reaction For The Determination Of Cobalt., Charles Gosse De Vries
LSU Historical Dissertations and Theses
No abstract provided.
Dielectric And Solvent Effects On The Alkaline Hydrolysis Of Ethyl-Acetate., James Edward Potts
Dielectric And Solvent Effects On The Alkaline Hydrolysis Of Ethyl-Acetate., James Edward Potts
LSU Historical Dissertations and Theses
No abstract provided.
The Migration Of Acyl Groups In Ortho-Aminophenols., Edgar Dumont Smith
The Migration Of Acyl Groups In Ortho-Aminophenols., Edgar Dumont Smith
LSU Historical Dissertations and Theses
No abstract provided.
The Cleavage Of Cyclo-Beta-Diketones. I. Tetramethyl-1,3-Cyclobutanedione. Ii. Tetraphenyl-1,3-Cyclobutanedione., Garry Carlton Kitchens
The Cleavage Of Cyclo-Beta-Diketones. I. Tetramethyl-1,3-Cyclobutanedione. Ii. Tetraphenyl-1,3-Cyclobutanedione., Garry Carlton Kitchens
LSU Historical Dissertations and Theses
No abstract provided.
The Decomposition Of Isopropyl Chlorocarbonate., Edgar Lattimore Compere
The Decomposition Of Isopropyl Chlorocarbonate., Edgar Lattimore Compere
LSU Historical Dissertations and Theses
No abstract provided.
The Reaction Of Beta-Hydroxy Ketones With Phenyl Magnesium-Bromide Keteneimines., Mack Castleman Fuqua
The Reaction Of Beta-Hydroxy Ketones With Phenyl Magnesium-Bromide Keteneimines., Mack Castleman Fuqua
LSU Historical Dissertations and Theses
No abstract provided.
The Kinetics And Mechanism Of The Alkaline Fading Of Iodo Phenol Blue - The Diacetone-Alcohol - Hydroxide Ion Reaction., Ralph Theodore Overman
The Kinetics And Mechanism Of The Alkaline Fading Of Iodo Phenol Blue - The Diacetone-Alcohol - Hydroxide Ion Reaction., Ralph Theodore Overman
LSU Historical Dissertations and Theses
No abstract provided.
The Kinetics Of The Decomposition Of Ethyl-Chlorocarbonate., George Francis Kirby
The Kinetics Of The Decomposition Of Ethyl-Chlorocarbonate., George Francis Kirby
LSU Historical Dissertations and Theses
No abstract provided.
Preparation And Properties Of Alpha Nitrogen Derivatives Of Furan., Henry Marvin Singleton
Preparation And Properties Of Alpha Nitrogen Derivatives Of Furan., Henry Marvin Singleton
LSU Historical Dissertations and Theses
No abstract provided.
Cleavage By Organic Magnesium Compounds., Maxwell Mcclelland Barnett
Cleavage By Organic Magnesium Compounds., Maxwell Mcclelland Barnett
LSU Historical Dissertations and Theses
No abstract provided.