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Full-Text Articles in Physical Sciences and Mathematics
Determination Of Metallic Constituents In Environmental And Biological Materials, Monique Erica Johnson
Determination Of Metallic Constituents In Environmental And Biological Materials, Monique Erica Johnson
Open Access Dissertations
Studies of the interaction of the relevant metal, metalloid or nanoparticulate species with biological systems are underpinned by the provision of reliable information about chemical composition of the relevant materials. Often, no methods of chemical analysis are available. The work described in this dissertation centers on developing methods to help with studies for a variety of analytes and samples. A method was developed for the determination of 11 trace elements (As, Cd, Co, Cr, Cu, Fe, Mg, Mn, Pb, Ti, and Zn) in human breast milk and infant formulas by inductively coupled plasma optical emission spectrometry (ICP-OES) following microwave-assisted digestion. …
Engineering Surface Functionality Of Gold Nanoparticles For Therapeutic Applications, Chaekyu Kim
Engineering Surface Functionality Of Gold Nanoparticles For Therapeutic Applications, Chaekyu Kim
Open Access Dissertations
Over the past few decades, tremendous efforts have been made to develop nanomaterials for biotechnological applications such as therapeutics. Understanding and engineering interfaces between biomacromolecules and nanomaterials is a key to the creation of successful therapeutic systems. My research has been oriented toward developing therapeutic systems using gold nanoparticles (AuNPs) incorporating material science, organic synthesis, and biology. For this purpose, mixed monolayer protected AuNPs (~2 nm core size) with various functional groups have been employed for triggering therapeutic effects. Several strategies have been accomplished using anticancer drugs that non-covalently and covalently incorporate onto AuNPs as a drug delivery carrier. Alternatively, …
Colloidal Microcapsules: Surface Engineering Of Nanoparticles For Interfacial Assembly, Debabrata Patra
Colloidal Microcapsules: Surface Engineering Of Nanoparticles For Interfacial Assembly, Debabrata Patra
Open Access Dissertations
Colloidal Microcapsules (MCs), i.e. capsules stabilized by nano-/microparticle shells are highly modular inherently multi-scale constructs with applications in many areas of material and biological sciences e.g. drug delivery, encapsulation and microreactors. These MCs are fabricated by stabilizing emulsions via self-assembly of colloidal micro/nanoparticles at liquid-liquid interface. In these systems, colloidal particles serve as modular building blocks, allowing incorporation of the particle properties into the functional capabilities of the MCs. As an example, nanoparticles (NPs) can serve as appropriate antennae to induce response by external triggers (e.g. magnetic fields or laser) for controlled release of encapsulated materials. Additionally, the dynamic nature …
Engineering Nanoparticles Surface For Biosensing: "Chemical Noses" To Detect And Identify Proteins, Bacteria And Cancerous Cells, Oscar Ramon Miranda-Sanchez
Engineering Nanoparticles Surface For Biosensing: "Chemical Noses" To Detect And Identify Proteins, Bacteria And Cancerous Cells, Oscar Ramon Miranda-Sanchez
Open Access Dissertations
Rapid and sensitive detection of biomolecules is an important issue in nanomedicine. Many disorders are manifested by changes in protein levels of serum and other biofluids. Rapid and effective differentiation between normal and cancerous cells is an important challenge for the diagnosis and treatment of tumor. Likewise, rapid and effective identification of pathogens is a key target in both biomedical and environmental monitoring. Most biological recognition processes occur via specific interactions. Gold nanoparticles (AuNPs) feature sizes commensurate with biomacromolecules, coupled with useful physical and optical properties. A key issue in the use of nanomaterials is controlling the interfacial interactions of …